- Name
2-Diethylaminoethylchloride hydrochloride
- EINECS212-786-4
- CAS No.
869-24-9
- Density1.1919 (rough estimate)
- PSA3.24000
- LogP2.36900
- Solubility2000 g/L (20 °C) in water
- Melting Point208-212 °C
- FormulaC6H14ClN.HCl
- Boiling Point114 °C at 760 mmHg
- Molecular Weight172.098
- Flash Point22.8 °C
- Transport InformationUN 2811 6.1/PG 2
- AppearanceColourless to beige crystals
- Safety26-36-45-36/37/39-28A
- Risk Codes22-36/37/38-26-24/25-23/24/25
- Molecular Structure
- Hazard SymbolsXn, T, Xi, T+
- SynonymsXn, T, Xi, T+
- Article Data13
2-Diethylaminoethylchloride hydrochloride Synthetic route
- 869-24-9
2-chloro-N,N-diethylethylamine hydrochloride
ConditionsConditions | Yield |
---|
Stage #1: 2-(Diethylamino)ethanol With thionyl chloride In dichloromethane at -10 - 35℃; for 2.5h; Stage #2: With hydrogenchloride | 98.08% |
With thionyl chloride; chloroform at -5℃; | |
With thionyl chloride In chloroform | |
- 869-24-9
2-chloro-N,N-diethylethylamine hydrochloride
ConditionsConditions | Yield |
---|
Stage #1: diethylamine; 2-chloro-ethanol for 4h; Reflux; Stage #2: With thionyl chloride In tetrachloromethane at 20℃; for 4h; | 46.6% |
Stage #1: diethylamine; 2-chloro-ethanol In toluene for 2h; Reflux; Stage #2: With thionyl chloride In toluene at 20℃; for 4h; Cooling with ice; | 3.3 g |
- 869-24-9
2-chloro-N,N-diethylethylamine hydrochloride
- 5449-19-4
1,1,4,4-tetraethyl-piperazinediium; dichloride
- 869-24-9
2-chloro-N,N-diethylethylamine hydrochloride
ConditionsConditions | Yield |
---|
With sodium carbonate In N,N-dimethyl-formamide at 33℃; Equilibrium constant; Decomposition; | |
5-hydroxymethyl-6-methylazepino[4,5-b]indole
A
1,2,3,4,5,6-hexahydro-3-diethylaminoethyl-5-hydroxymethyl-6-methylazepino[4,5-b]indole
B
- 869-24-9
2-chloro-N,N-diethylethylamine hydrochloride
trans-N-[4-(2-Diethylamino-ethoxy)-cyclohexyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide
A
trans-N-(4-hydroxy-cyclohexyl)-N-methyl-4-trifluoro-methyl-benzenesulfonamide
B
- 869-24-9
2-chloro-N,N-diethylethylamine hydrochloride
- 869-24-9
2-chloro-N,N-diethylethylamine hydrochloride
- 72030-42-3
3-methyl-1,8-dihydrocycloheptapyrazol-8-one
- 136052-98-7
1-<2-(diethylamino)ethyl>-3-methyl-1,8-dihydrocycloheptapyrazol-8-one
ConditionsConditions | Yield |
---|
With potassium carbonate In acetone for 6h; Heating; | 100% |
- 869-24-9
2-chloro-N,N-diethylethylamine hydrochloride
methyl 4-butoxy-3-(2-diethylaminoethoxy)benzoate hydrochloride
ConditionsConditions | Yield |
---|
With potassium carbonate In acetone for 16h; Heating; | 100% |
2-oxo-7-(trifluoromethyl)-1-[3-(trifluoromethyl)benzyl]-2,3-dihydro-1H-benzimidazole-5-carbonitrile
- 869-24-9
2-chloro-N,N-diethylethylamine hydrochloride
3-[2-(diethylamino)ethyl]-2-oxo-7-(trifluoromethyl)-1-[3-(trifluoromethyl)benzyl]-2,3-dihydro-1H-benzimidazole-5-carbonitrile
ConditionsConditions | Yield |
---|
Stage #1: 2-oxo-7-(trifluoromethyl)-1-[3-(trifluoromethyl)benzyl]-2,3-dihydro-1H-benzimidazole-5-carbonitrile With sodium hydride In DMF (N,N-dimethyl-formamide) at 20℃; for 0.166667h; Stage #2: 2-chloro-N,N-diethylethylamine hydrochloride With triethylamine In DMF (N,N-dimethyl-formamide) at 70℃; for 1.5h; | 100% |
1,2-dihydrocyclopenta[e]thieno[2,3-b]indol-3(6H)-one
- 869-24-9
2-chloro-N,N-diethylethylamine hydrochloride
6-(2-(diethylamino)ethyl)-1,2-dihydrocyclopenta[e]thieno[2,3-b]indol-3(6H)-one
ConditionsConditions | Yield |
---|
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 16h; | 100% |
2-Diethylaminoethylchloride hydrochloride Chemical Properties
Molecular Formula: C
6H
15Cl
2N
Formula Weight: 172.1
mp of 2-CHLOROTRIETHYLAMINE HYDROCHLORIDE (869-24-9): 50-53
°C(lit.)
Boiling Point: 114
°C at 760 mmHg
Flash Point: 22.8
°C
storage temp. : Poison room
Vapour Pressure: 20.3 mmHg at 25
°C
solubility of 2-CHLOROTRIETHYLAMINE HYDROCHLORIDE (869-24-9): methanol: 0.1 g/mL, clear, colorless
Water Solubility : 2000 g/L (20
oC)
Sensitive : Moisture Sensitive
Appearence of 2-CHLOROTRIETHYLAMINE HYDROCHLORIDE (869-24-9): Colourless to beige crystals
2-Diethylaminoethylchloride hydrochloride Uses
2-CHLOROTRIETHYLAMINE HYDROCHLORIDE (869-24-9) is used as an organic synthesis intermediate for the syntheses of pharmaceuticals (e.g. amiodarone, butetamate citrate, flurazepam and naftidrofuryl).
2-Diethylaminoethylchloride hydrochloride Production
β-Diethylaminoethanol reacts with thionyl chloride to form 2-CHLOROTRIETHYLAMINE HYDROCHLORIDE (869-24-9).
2-Diethylaminoethylchloride hydrochloride Toxicity Data With Reference
1. | | mmo-sat 500 µmol/L | | ENMUDM Environmental Mutagenesis. 3 (1981),11. |
2. | | mmo-esc 1 µmol/L | | JPPMAB Journal of Pharmacy and Pharmacology. 31 (1979),67P. |
3. | | dns-rat:lvr 100 µmol/L | | ENMUDM Environmental Mutagenesis. 3 (1981),11. |
4. | | msc-mus:lym 22 µmol/L | | ENMUDM Environmental Mutagenesis. 3 (1981),33. |
5. | | ipr-rat LD50:30 mg/kg | | CPBTAL Chemical and Pharmaceutical Bulletin. 8 (1960),807. |
6. | | orl-mus LDLo:320 mg/kg | | AECTCV Archives of Environmental Contamination and Toxicology. 14 (1985),111. |
7. | | ipr-mus LD50:71 mg/kg | | JPETAB Journal of Pharmacology and Experimental Therapeutics. 94 (1948),249. |
8. | | scu-mus LD50:100 mg/kg | | JPETAB Journal of Pharmacology and Experimental Therapeutics. 91 (1947),224. |
9. | | ivn-mus LD50:100 mg/kg | | JPETAB Journal of Pharmacology and Experimental Therapeutics. 91 (1947),224. |
10. | | ivn-rbt LDLo:40 mg/kg | | JPETAB Journal of Pharmacology and Experimental Therapeutics. 91 (1947),224. |
|
2-Diethylaminoethylchloride hydrochloride Consensus Reports
Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
2-Diethylaminoethylchloride hydrochloride Safety Profile
Safety: DANGER: POISON, causes CNS injury
Hazard Codes : Xn,T,Xi,T+ (Harmful; Toxic; Irritant; Very Toxic)
Risk Statements : 22-36/37/38-26-24/25-23/24/25 (Harmful if swallowed; Irritating to eyes, respiratory system and skin; Very Toxic by inhalation; Toxic in contact with skin and if swallowed; Toxic by inhalation, in contact with skin and if swallowed)
Safety Statements : 26-36-45-36/37/39-28A (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Wear suitable protective clothing; In case of accident or if you feel unwell, seek medical advice immediately; Wear suitable protective clothing, gloves and eye/face protection; After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer))
RIDADR : UN 2811 6.1/PG 2
WGK Germany : 3
RTECS : DC2810000
Hazard Note : Irritant/Very Toxic
HazardClass : 6.1
PackingGroup : II
HS Code : 29211980
Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl
− and NO
x. See also
AMINES and
CHLORIDES.
2-Diethylaminoethylchloride hydrochloride Standards and Recommendations
ASSAY (TITRIMETRIC): 99.5% min
CHLORINE: 40.0 - 42.0%
CHLORIDE: 20.0 - 21.0%
LOSS ON DRYING: 0.5% max
2-Diethylaminoethylchloride hydrochloride Specification
Storage: Take precautions to avoid contact with atmospheric moisture. 2-CHLOROTRIETHYLAMINE HYDROCHLORIDE (869-24-9) is hygroscopic. Store in tightly sealed containers in a cool place.