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5-bromo2-nitropyridine
5-bromo-2-fluoropyridine
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran; water; N,N-dimethyl-formamide at 23℃; for 4h; | |
With p-methoxybenzoyl fluoride; 2,3-Dihydro-1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene In N,N-dimethyl-formamide at 25℃; for 16h; Inert atmosphere; | 91 %Spectr. |
Conditions | Yield |
---|---|
With bromine; mercury(II) oxide In tetrachloromethane; hexane | 1.73 g (63%) |
5-bromo-2-chloropyridine
5-bromo-2-fluoropyridine
Conditions | Yield |
---|---|
With p-methoxybenzoyl fluoride; 2,3-Dihydro-1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene In N,N-dimethyl-formamide at 25℃; for 16h; Inert atmosphere; | 80 %Spectr. |
With tetramethylammonium fluoride In N,N-dimethyl-formamide at 25℃; for 24h; Sealed tube; | 100 %Spectr. |
3-Hydroxytetrahydrofuran
5-bromo-2-fluoropyridine
rac-5-bromo-2-(tetrahydro-furan-3-yloxy)-pyridine
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 90℃; for 72h; | 100% |
With caesium carbonate In N,N-dimethyl-formamide at 90℃; for 70h; Sealed tube; Inert atmosphere; | 93% |
5-bromo-2-fluoropyridine
4-trifluoromethoxyphenylboronic acid
2-fluoro-5-[4-(trifluoromethoxy)phenyl]pyridine
Conditions | Yield |
---|---|
With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In ethanol; water; toluene at 85 - 88℃; for 3h; Inert atmosphere; | 100% |
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; sodium carbonate In ethanol; toluene at 85 - 88℃; for 3h; Suzuki Coupling; Inert atmosphere; | 100% |
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran at -78℃; | 100% |
With n-butyllithium In tetrahydrofuran at -78℃; |
Conditions | Yield |
---|---|
Stage #1: 3,4-dichlorobenzyl alcohol With sodium hydride In tetrahydrofuran at 0 - 20℃; for 1.5h; Reflux; Stage #2: 5-bromo-2-fluoropyridine In tetrahydrofuran for 12h; Reflux; | 100% |
Conditions | Yield |
---|---|
Stage #1: (3,4,5-trimethoxyphenyl)methanol With sodium hydride In tetrahydrofuran at 0 - 20℃; for 1.5h; Reflux; Stage #2: 5-bromo-2-fluoropyridine In tetrahydrofuran for 12h; Reflux; | 100% |
5-bromo-2-fluoropyridine
phenylmethanethiol
2-(benzylsulfanyl)-5-bromopyridine
Conditions | Yield |
---|---|
Stage #1: phenylmethanethiol With sodium hydride In tetrahydrofuran at 0 - 20℃; for 1.5h; Reflux; Stage #2: 5-bromo-2-fluoropyridine In tetrahydrofuran for 12h; Reflux; | 100% |
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 2h; |
Conditions | Yield |
---|---|
Stage #1: cuminol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 1h; Stage #2: 5-bromo-2-fluoropyridine In N,N-dimethyl-formamide; mineral oil at 20℃; for 72h; | 100% |
Stage #1: cuminol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 1h; Stage #2: 5-bromo-2-fluoropyridine In N,N-dimethyl-formamide; mineral oil at 20℃; for 72h; | 100% |
The 2-Fluoro-5-bromopyridine, with the CAS registry number 766-11-0, has the systematic name of 5-bromo-2-fluoropyridine. It is a kind of clear colorless yellowish liquid, and belongs to the following product categories: Fluorin-contained pyridine series; blocks; Bromides; Pyridines; Pharmacetical; Pyridines derivates; Halogenated; Organohalides; Bromopyridines; Fluoropyridines; Halopyridines; Boronic Acid; Heterocyclic Building Blocks; Halogenated Heterocycles; Variety of halogenated heterocyclic series. The molecular formula of this chemical is C5H3BrFN.
The physical properties of 2-Fluoro-5-bromopyridine are as followings: (1)ACD/LogP: 1.80; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.8; (4)ACD/LogD (pH 7.4): 1.8; (5)ACD/BCF (pH 5.5): 13.68; (6)ACD/BCF (pH 7.4): 13.68; (7)ACD/KOC (pH 5.5): 226.35; (8)ACD/KOC (pH 7.4): 226.35; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 12.89 Å2; (13)Index of Refraction: 1.533; (14)Molar Refractivity: 32.02 cm3; (15)Molar Volume: 103 cm3; (16)Polarizability: 12.69×10-24cm3; (17)Surface Tension: 39.9 dyne/cm; (18)Density: 1.707 g/cm3; (19)Flash Point: 61.4 °C; (20)Enthalpy of Vaporization: 39.73 kJ/mol; (21)Boiling Point: 178 °C at 760 mmHg; (22)Vapour Pressure: 1.37 mmHg at 25°C.
You should be cautious while dealing with this chemical. It irritates to eyes, respiratory system and skin, and it is also harmful by inhalation, in contact with skin and if swallowed. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)SMILES: Brc1cnc(F)cc1
(2)InChI: InChI=1/C5H3BrFN/c6-4-1-2-5(7)8-3-4/h1-3H
(3)InChIKey: MYUQKYGWKHTRPG-UHFFFAOYAV