2-Methoxy-5-nitropyridine

The 2-Methoxy-5-nitropyridine is also its IUPAC name of this chemical. With cas registry number of 5446-92-4, this chemical belongs to a kind of classes in blocks; Pyridines; Pyridine; Pyridines, Pyrimidines, Purines and Pteredines; Pyridines derivates; Boronic Acid; C6; Heterocyclic Building Blocks. Its EINECS registry number is 226-661-7 with appearance of very slightly yellow adhering powder.

Physical properties about this chemical are: (1)ACD/LogP: 1.33; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.33; (4)ACD/LogD (pH 7.4): 1.33; (5)ACD/BCF (pH 5.5): 6.02; (6)ACD/BCF (pH 7.4): 6.02; (7)ACD/KOC (pH 5.5): 125.85; (8)ACD/KOC (pH 7.4): 125.85; (9)#H bond acceptors: 5; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.546; (13)Molar Refractivity: 37.56 cm³; (14)Molar Volume: 118.5 cm³; (15)Surface Tension: 49 dyne/cm; (16)Density: 1.3 g/cm³; (17)Flash Point: 110.4 °C; (18)Enthalpy of Vaporization: 47.65 kJ/mol; (19)Boiling Point: 258.9 °C at 760 mmHg; (20)Vapour Pressure: 0.0216 mmHg at 25°C.

Preparation of 2-Methoxy-5-nitropyridine: this chemical can be made by reaction of 2-chloro-5-nitro-pyridine with methanol using reagent NaH, solvent tetrahydrofuran under Ambient temperature. The reaction time is 1 hour with 82% yield.

Uses of 2-Methoxy-5-nitropyridine: it can be used to prepare 6-methoxy-pyridin-3-ylamine using reagents iron-powder, acetic acid, and aqueous methanol.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. Wear suitable protective clothing, gloves and eye/face protection during using it. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: COC1=NC=C(C=C1)[N+](=O)[O-];
(2)InChI: InChI=1S/C6H6N2O3/c1-11-6-3-2-5(4-7-6)8(9)10/h2-4H,1H3;
(3)InChIKey: WUPLOZFIOAEYMG-UHFFFAOYSA-N