Basic information
- Name:
3-Aminopyridine
- CAS No.:
462-08-8
- Molecular Structure:
- Formula:
- C5H6N2
- Molecular Weight:
- 94.12
- Synonyms:
- pyridin-3-amine;Amino-3 pyridine;3-Pyridinamine;;3-Amino Pyridine;3-Pyridylamine;Pyridine, 3-amino-;beta-Aminopyridine;
- EINECS:
- 207-322-2
- Density:
- 1.107 g/cm3
- Melting Point:
- 60-63 ºC(lit.)
- Boiling Point:
- 251 ºC at 760 mmHg
- Flash Point:
- 126 ºC
- Appearance:
- white to light yellow crystal powder
- Hazard Symbols:
Xi,
T- Risk Codes:
- 23/24/25-33-36/37/38
- Safety Description:
- 36/37/39-45-28-26 Details
- Transport Information:
- UN 2671 6.1/PG 2
Famous Chemical Enterprises
-
Livzon -
Total -
Shell -
Dupont -
Exxonmobil -
Akzonobel -
Basf -
Bayer -
BP
Please post your buying leads,so that our qualified suppliers will soon
contact you!
*Required Fields
Consensus Reports
Reported in EPA TSCA Inventory.
Standards and Recommendations
DOT Classification: 6.1; Label: Poison
Specification
The 3-Aminopyridine, with the CAS registry number 462-08-8, is also known as 3-Pyridinamine. It belongs to the product categories of Fine Chemical & Intermediates; Pyridine; Organics; Pyridine Series; Pyridines Derivates. Its EINECS registry number is 207-322-2. This chemical's molecular formula is C5H6N2 and molecular weight is 94.11. What's more, both its IUPAC name and systematic name are the same which is called Pyridin-3-amine. 3-Aminopyridine is an aminopyridine. This chemical can be prepared by nicotinamide.
Physical properties about 3-Aminopyridine are: (1)# of Rule of 5 Violations: 0; (2)#H bond acceptors: 2; (3)#H bond donors: 2; (4)#Freely Rotating Bonds: 1; (5)Polar Surface Area: 38.91 Å2; (6)Index of Refraction: 1.587; (7)Molar Refractivity: 28.58 cm3; (8)Molar Volume: 84.9 cm3; (9)Surface Tension: 51.2 dyne/cm; (10)Density: 1.107 g/cm3; (11)Flash Point: 126 °C; (12)Enthalpy of Vaporization: 48.83 kJ/mol; (13)Boiling Point: 251 °C at 760 mmHg; (14)Vapour Pressure: 0.021 mmHg at 25 °C.
Uses of 3-Aminopyridine: (1) it is used for intermediates of medicine and dye and it also can be used as analytical reagent; (2) it is used to produce other chemicals. For example, it can react with Formaldehyde to get Dimethyl-pyridin-3-yl-amine. The reaction occurs with reagents H2SO4 and zinc-powder.
When you are dealing with this chemical, you should be very careful. This chemical is toxic by inhalation, in contact with skin and if swallowed. It is irritating to eyes, respiratory system and skin. Therefore, you could take off immediately all contaminated clothing. And you must wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1) SMILES: Nc1cccnc1
(2) InChI: InChI=1S/C5H6N2/c6-5-2-1-3-7-4-5/h1-4H,6H2
(3) InChIKey: CUYKNJBYIJFRCU-UHFFFAOYSA-N
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| bird - wild | LD50 | oral | 13300ug/kg (13.3mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. | |
| mouse | LD50 | intracrebral | 4mg/kg (4mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Australian Journal of Experimental Biology and Medical Science. Vol. 36, Pg. 365, 1958. |
| mouse | LD50 | intraperitoneal | 28mg/kg (28mg/kg) | Journal of Medicinal Chemistry. Vol. 8, Pg. 296, 1965. | |
| mouse | LD50 | intravenous | 24mg/kg (24mg/kg) | Annales Pharmaceutiques Francaises. Vol. 26, Pg. 345, 1968. | |
| mouse | LD50 | subcutaneous | 30mg/kg (30mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 226, Pg. 163, 1955. | |
| quail | LD50 | oral | 178mg/kg (178mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. |
