5-Fluorouridine (316-46-1),5-Fluorouridine (316-46-1) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
5-Fluorouridine
CAS No.:
316-46-1
Molecular Structure:
Formula:
C₉H₁₁FN₂O₆
Molecular Weight:
262.19
Synonyms:
1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-pyrimidine-2,4-dione;Uridine, 5-fluoro- (8CI 9CI);1-((2S,3S,4R,5S)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-fluoro-1-H-pyrimidine-2,4-dione;5-Fluoro-1-.beta.-D-ribofuranosyluracil;5-Fluoro-uridine;1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-pyrimidine-2,4-dione;Uridine, 5-fluoro-;4-24-00-01231 (Beilstein Handbook Reference);Fluorouridine;L-5-Fluorouridine;L-.beta.-Ribofuranosyl-5-fluorouracil;5-Fur;1-[(2S,3S,4S,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-pyrimidine-2,4-dione;
EINECS:
206-260-3
Density:
1.77 g/cm³
Melting Point:
182-184 °C
Solubility:
Soluble in water
Appearance:
White powder
Hazard Symbols:
Xn, Xi
Risk Codes:
40-68-36/37/38
Safety Description:
22-26-36/37-36/37/39-27 Details

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Chemistry

Structure of 5-Fluorouridine (CAS NO.316-46-1):

IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoropyrimidine-2,4-dione
Empirical Formula: C₉H₁₁FN₂O₆
Molecular Weight: 262.1918
EINECS: 206-260-3
Index of Refraction: 1.641
Molar Refractivity: 53.45 cm³
Molar Volume: 148.1 cm³
Polarizability: 21.19×10^-24cm³
Surface Tension: 87.1 dyne/cm
Density: 1.77 g/cm³
Melting Point: 182-184 °C
Water Solubility: soluble
Physical Appearance: White Powder
Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Pyrimidine;Nucleotides and Nucleosides;Biochemistry;Chemical Reagents for Pharmacology Research;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents;Bases & Related Reagents;Nucleotides

Uses

5-Fluorouridine (CAS NO.316-46-1) can be used for producing intermediates of anticancer drug DFUR and FUDR ,and also can be used in genetic engineering and biochemical reagents and so on.

Toxicity Data With Reference

1.	dns-hmn:hla 10 µmol/L	BCPCA6 Biochemical Pharmacology. 14 (1965),205.
2.	dni-mus-ipr 500 µmol/kg	CNREA8 Cancer Research. 39 (1979),2406.
3.	ipr-rat LD50:400 mg/kg	ADTEAS Advances in Teratology. 3 (1968),181.
4.	ipr-mus LD50:160 mg/kg	CNREA8 Cancer Research. 39 (1979),2406.
5.	scu-mus LD50:384 mg/kg	CNCRA6 Cancer Chemotherapy Reports. 6 (1960),94.

Safety Profile

Poison by intraperitoneal and subcutaneous routes. Human mutation data reported. When heated to decomposition it emits very toxic fumes of F⁻ and NO_x.
Hazard Codes:Xn,Xi
Risk Statements:
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
40: Limited evidence of a carcinogenic effect
68: Possible risk of irreversible effectsSafety Statements:
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
27: Take off immediately all contaminated clothing
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
WGK Germany: 3
RTECS: YU8050000
F: 10
Hazard Note: Harmful

Specification

5-Fluorouridine , its cas register number is 316-46-1. It also can be called 2(1H)-pyrimidinone, 5-fluoro-4-hydroxy-1-pentofuranosyl- ; 2,4(1H,3H)-pyrimidinedione, 5-fluoro-1-pentofuranosyl- ; 5-Fluoro-1-pentofuranosylpyrimidine-2,4(1H,3H)-dione ; (2'R,3'R,4'S,5'R)-1-(3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-fluoro-1H-pyrimidine-2,4-dione ; 1-(3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-fluoro-1H-pyrimidine-2,4-dione .