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Cas Database

Name	5-Fluorouridine	EINECS	206-260-3
CAS No.	316-46-1	Density	1.77 g/cm³
PSA	124.78000	LogP	-2.71280
Solubility	Soluble in water	Melting Point	182-184 °C
Formula	C₉H₁₁FN₂O₆	Boiling Point	N/A
Molecular Weight	262.195	Flash Point	N/A
Transport Information	N/A	Appearance	White powder
Safety	22-26-36/37-36/37/39-27	Risk Codes	40-68-36/37/38
Molecular Structure		Hazard Symbols	Xn, Xi
Synonyms	1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-pyrimidine-2,4-dione;Uridine, 5-fluoro- (8CI 9CI);1-((2S,3S,4R,5S)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-fluoro-1-H-pyrimidine-2,4-dione;5-Fluoro-1-.beta.-D-ribofuranosyluracil;5-Fluoro-uridine;1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-pyrimidine-2,4-dione;Uridine, 5-fluoro-;4-24-00-01231 (Beilstein Handbook Reference);Fluorouridine;L-5-Fluorouridine;L-.beta.-Ribofuranosyl-5-fluorouracil;5-Fur;1-[(2S,3S,4S,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-pyrimidine-2,4-dione;	Article Data	38

5-Fluorouridine Chemical Properties

Structure of 5-Fluorouridine (CAS NO.316-46-1):

IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoropyrimidine-2,4-dione
Empirical Formula: C₉H₁₁FN₂O₆
Molecular Weight: 262.1918
EINECS: 206-260-3
Index of Refraction: 1.641
Molar Refractivity: 53.45 cm³
Molar Volume: 148.1 cm³
Polarizability: 21.19×10^-24cm³
Surface Tension: 87.1 dyne/cm
Density: 1.77 g/cm³
Melting Point: 182-184 °C
Water Solubility: soluble
Physical Appearance: White Powder
Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Pyrimidine;Nucleotides and Nucleosides;Biochemistry;Chemical Reagents for Pharmacology Research;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents;Bases & Related Reagents;Nucleotides

5-Fluorouridine Uses

5-Fluorouridine (CAS NO.316-46-1) can be used for producing intermediates of anticancer drug DFUR and FUDR ,and also can be used in genetic engineering and biochemical reagents and so on.

5-Fluorouridine Toxicity Data With Reference

1.	dns-hmn:hla 10 µmol/L	BCPCA6 Biochemical Pharmacology. 14 (1965),205.
2.	dni-mus-ipr 500 µmol/kg	CNREA8 Cancer Research. 39 (1979),2406.
3.	ipr-rat LD50:400 mg/kg	ADTEAS Advances in Teratology. 3 (1968),181.
4.	ipr-mus LD50:160 mg/kg	CNREA8 Cancer Research. 39 (1979),2406.
5.	scu-mus LD50:384 mg/kg	CNCRA6 Cancer Chemotherapy Reports. 6 (1960),94.

5-Fluorouridine Safety Profile

Poison by intraperitoneal and subcutaneous routes. Human mutation data reported. When heated to decomposition it emits very toxic fumes of F⁻ and NO_x.
Hazard Codes:Xn,Xi
Risk Statements:
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
40: Limited evidence of a carcinogenic effect
68: Possible risk of irreversible effectsSafety Statements:
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
27: Take off immediately all contaminated clothing
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
WGK Germany: 3
RTECS: YU8050000
F: 10
Hazard Note: Harmful

5-Fluorouridine Specification

5-Fluorouridine , its cas register number is 316-46-1. It also can be called 2(1H)-pyrimidinone, 5-fluoro-4-hydroxy-1-pentofuranosyl- ; 2,4(1H,3H)-pyrimidinedione, 5-fluoro-1-pentofuranosyl- ; 5-Fluoro-1-pentofuranosylpyrimidine-2,4(1H,3H)-dione ; (2'R,3'R,4'S,5'R)-1-(3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-fluoro-1H-pyrimidine-2,4-dione ; 1-(3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-fluoro-1H-pyrimidine-2,4-dione .

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