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Name	5-Methoxypyridine-2-carboxlic acid	EINECS	1533716-785-6
CAS No.	29082-92-6	Density	1.285 g/cm³
PSA	59.42000	LogP	0.78840
Solubility	N/A	Melting Point	172-174 °C
Formula	C₇H₇NO₃	Boiling Point	312.883 °C at 760 mmHg
Molecular Weight	153.137	Flash Point	143.027 °C
Transport Information	N/A	Appearance	N/A
Safety		Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	5-Methoxy-2-pyridinecarboxylic acid;Picolinicacid, 5-methoxy- (8CI);5-Methoxypicolinicacid;

5-Methoxypyridine-2-carboxlic acid Synthetic route

: 15069-92-8
5-hydroxypicolinic acid

: 74-88-4
methyl iodide

: 29082-92-6
5-methoxypyridine-2-carboxylic acid

Conditions

Conditions	Yield
With silver(l) oxide In dimethyl sulfoxide for 2h; Ambient temperature;	48%

: 24242-20-4
5-amino-pyridine-2-carboxylic acid

: 29082-92-6
5-methoxypyridine-2-carboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1) conc. H2SO4, NaNO2; 2) conc. H2SO4 / 1) H2O, 0 deg C, 5 min; 2) reflux, H2O 2: 48 percent / Ag2O / dimethylsulfoxide / 2 h / Ambient temperature View Scheme

: 4214-76-0
5-nitro-pyridin-2-ylamine

: 29082-92-6
5-methoxypyridine-2-carboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 1.) 48 percent HBr, Br2; 2.) NaNO2 / 1) 30-40 deg C; 2) -5 deg C, H2O; 10-15 Deg C, 90 min.; 3) 40 deg C. 15 min 2: dimethylsulfoxide / 0.08 h / 180 °C 3: 54 percent / HCl / 1.5 h / Heating 4: 70 percent / H2S, 25 percent NH3 5: 1) conc. H2SO4, NaNO2; 2) conc. H2SO4 / 1) H2O, 0 deg C, 5 min; 2) reflux, H2O 6: 48 percent / Ag2O / dimethylsulfoxide / 2 h / Ambient temperature View Scheme

Yield

Multi-step reaction with 6 steps
1: 1.) 48 percent HBr, Br2; 2.) NaNO2 / 1) 30-40 deg C; 2) -5 deg C, H2O; 10-15 Deg C, 90 min.; 3) 40 deg C. 15 min
2: dimethylsulfoxide / 0.08 h / 180 °C
3: 54 percent / HCl / 1.5 h / Heating
4: 70 percent / H2S, 25 percent NH3
5: 1) conc. H2SO4, NaNO2; 2) conc. H2SO4 / 1) H2O, 0 deg C, 5 min; 2) reflux, H2O
6: 48 percent / Ag2O / dimethylsulfoxide / 2 h / Ambient temperature
View Scheme

: 4487-59-6
2-bromo-5-nitropyridine

: 29082-92-6
5-methoxypyridine-2-carboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: dimethylsulfoxide / 0.08 h / 180 °C 2: 54 percent / HCl / 1.5 h / Heating 3: 70 percent / H2S, 25 percent NH3 4: 1) conc. H2SO4, NaNO2; 2) conc. H2SO4 / 1) H2O, 0 deg C, 5 min; 2) reflux, H2O 5: 48 percent / Ag2O / dimethylsulfoxide / 2 h / Ambient temperature View Scheme

: 100367-55-3
5-nitropyridine-2-carbonitrile

: 29082-92-6
5-methoxypyridine-2-carboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 54 percent / HCl / 1.5 h / Heating 2: 70 percent / H2S, 25 percent NH3 3: 1) conc. H2SO4, NaNO2; 2) conc. H2SO4 / 1) H2O, 0 deg C, 5 min; 2) reflux, H2O 4: 48 percent / Ag2O / dimethylsulfoxide / 2 h / Ambient temperature View Scheme

: 30651-24-2
5-nitropicolinic acid

: 29082-92-6
5-methoxypyridine-2-carboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 70 percent / H2S, 25 percent NH3 2: 1) conc. H2SO4, NaNO2; 2) conc. H2SO4 / 1) H2O, 0 deg C, 5 min; 2) reflux, H2O 3: 48 percent / Ag2O / dimethylsulfoxide / 2 h / Ambient temperature View Scheme

: 55270-47-8
5-methoxy-2-picoline

: 29082-92-6
5-methoxypyridine-2-carboxylic acid

Conditions

Conditions	Yield
With potassium permanganate In water; toluene
With potassium permanganate In water; toluene
With pyridine; selenium(IV) oxide for 62h; Heating / reflux;

: 89809-63-2
5-methoxypyridine-2-carbonitrile

: 29082-92-6
5-methoxypyridine-2-carboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride; water Heating / reflux;

: 105170-27-2
2-bromo-5-methoxypyridine

: 29082-92-6
5-methoxypyridine-2-carboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 24 h / 100 °C / 37503.8 Torr 2: water; lithium hydroxide monohydrate / methanol / 12 h / 10 - 35 °C View Scheme

: 29681-39-8
5-methoxypyridine-2-carboxylic acid methyl ester

: 29082-92-6
5-methoxypyridine-2-carboxylic acid

Conditions

Conditions	Yield
With lithium hydroxide monohydrate; water In methanol at 10 - 35℃; for 12h;	2.4 g

5-Methoxypyridine-2-carboxlic acid Chemical Properties

Systematic Name: 5-Methoxypyridine-2-carboxylic acid
Synonyms of 5-Methoxypyridine-2-carboxlic acid (CAS NO.29082-92-6): 5-Methoxy-2-pyridinecarboxylic acid
CAS NO: 29082-92-6
Molecular Formula: C₇H₇NO₃
Molecular Weight: 153.13
Molecular Structure:
H bond acceptors: 4
H bond donors: 1
Freely Rotating Bonds: 2
Polar Surface Area: 59.42 Å²
Index of Refraction: 1.55
Molar Refractivity: 37.953 cm³
Molar Volume: 119.189 cm³
Surface Tension: 52.101 dyne/cm
Density: 1.285 g/cm³
Flash Point: 143.027 °C
Enthalpy of Vaporization: 58.483 kJ/mol
Boiling Point: 312.883 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C
SMILES: O=C(O)c1ncc(OC)cc1
InChI: InChI=1/C7H7NO3/c1-11-5-2-3-6(7(9)10)8-4-5/h2-4H,1H3,(H,9,10)
InChIKey: YPKUGKJFOOZLHN-UHFFFAOYAI
Std. InChI: InChI=1S/C7H7NO3/c1-11-5-2-3-6(7(9)10)8-4-5/h2-4H,1H3,(H,9,10)
Std. InChIKey: YPKUGKJFOOZLHN-UHFFFAOYSA-N
Product Categories of 5-Methoxypyridine-2-carboxlic acid (CAS NO.29082-92-6): Pyridines

5-Methoxypyridine-2-carboxlic acid Uses

5-Methoxypyridine-2-carboxlic acid (CAS NO.29082-92-6) is used as pharmaceutical intermediate.

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