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Cas Database

Name	6-Chloronicotinamide	EINECS	228-456-8
CAS No.	6271-78-9	Density	1.381 g/cm³
PSA	55.98000	LogP	1.53420
Solubility	N/A	Melting Point	210-212 °C(lit.)
Formula	C₆H₅ClN₂O	Boiling Point	331 °C at 760 mmHg
Molecular Weight	156.572	Flash Point	154 °C
Transport Information	N/A	Appearance	N/A
Safety	26-36/37/39-22	Risk Codes	36/37/38-20/21/22
Molecular Structure		Hazard Symbols	Xn
Synonyms	Nicotinamide,6-chloro- (6CI,7CI,8CI);2-Chloro-5-carbamoylpyridine;6-Chloro-3-pyridinecarboxamide;6-Chloronicotinamide;NSC 37821;	Article Data	13

6-Chloronicotinamide Synthetic route

: 33252-28-7
6-chloronicotinonitrile

: 6271-78-9
6-chloro-3-pyridinecarboxamide

Conditions

Conditions	Yield
With manganese(IV) oxide; water In isopropyl alcohol at 50℃; under 5171.62 Torr; for 0.166667h;	99%

: 39891-09-3
(6-chloro-pyridin-3-yl)-acetonitrile

: 6271-78-9
6-chloro-3-pyridinecarboxamide

Conditions

Conditions	Yield
With ammonium hydroxide; 5 wt% ruthenium/carbon; oxygen In tetrahydrofuran at 30℃; for 20h;	86%

: 33252-28-7
6-chloronicotinonitrile

: 917-64-6
methyl magnesium iodide

: 60-29-7
diethyl ether

A: 6271-78-9
6-chloro-3-pyridinecarboxamide

B: 55676-22-7
3-acetyl-6-chloropyridine

: 5006-66-6
6-hydroxy-3-pyridinecarboxylic acid

: 6271-78-9
6-chloro-3-pyridinecarboxamide

Conditions

Conditions	Yield
With phosphorus pentachloride; trichlorophosphate at 120℃; Behandeln des entstandenen 6-Chlor-nicotinsaeure-chlorid mit Benzol und Ammoniak;
With trichlorophosphate Behandeln des Reaktionsprodukts in Aceton mit wss. NH3;

: 6311-35-9
6-bromonicotinic acid

: 6271-78-9
6-chloro-3-pyridinecarboxamide

Conditions

Conditions	Yield
With oxalyl dichloride; benzene Behandeln des Reaktionsgemisches mit wss. NH3;

: 3670-59-5
6-hydroxynicotinamide

: 6271-78-9
6-chloro-3-pyridinecarboxamide

Conditions

Conditions	Yield
With ammonium hydroxide; phosphorus pentachloride; trichlorophosphate

: 58757-38-3
6-Chloronicotinoyl chloride

: 6271-78-9
6-chloro-3-pyridinecarboxamide

Conditions

Conditions	Yield
With ammonia In toluene at 20℃; for 8h;	7.15 g
With ammonia In diethyl ether	9 g
With ammonia In water at 0℃; for 0.5h;

: 5326-23-8
6-Chloro-3-pyridinecarboxylic acid

: 6271-78-9
6-chloro-3-pyridinecarboxamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: SOCl2 / 4 h / Heating 2: 9 g / NH3 gas / diethyl ether View Scheme
Multi-step reaction with 2 steps 1: SOCl2 / 15 h / Heating 2: 7.15 g / NH3*H2O / toluene / 8 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 25 °C 2: ammonia / water / 0.5 h / 0 °C View Scheme

: 18368-64-4
2-chloro-5-methylpyridine

: 6271-78-9
6-chloro-3-pyridinecarboxamide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 60.1 percent / KMnO4 / H2O / 5 h / Heating 2: SOCl2 / 15 h / Heating 3: 7.15 g / NH3*H2O / toluene / 8 h / 20 °C View Scheme

: 1603-41-4
(5-methyl-pyridin-2-yl)amine

: 6271-78-9
6-chloro-3-pyridinecarboxamide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: bromine; aqueous sodium nitrite solution; aqueous hydrobromic acid 2: aqueous KMnO4 3: oxalyl chloride; benzene / Behandeln des Reaktionsgemisches mit wss. NH3 View Scheme

6-Chloronicotinamide Chemical Properties

Molecular Formula: C₆H₅ClN₂O
Molar mass: 156.5697 g/mol
Density: 1.381 g/cm³
Flash Point: 154 °C
Index of Refraction: 1.588
Melting point: 210-212 °C(lit.)
Boiling Point: 331 °C at 760 mmHg
Vapour Pressure: 0.00016 mmHg at 25°C
Structure of 6-Chloronicotinamide(6271-78-9):

Synonyms of 6-Chloronicotinamide(6271-78-9): 6-chloropyridine-3-carboxamide ;Nicotinamide, 6-chloro- ;3-Pyridinecarboxamide, 6-chloro- ;2-Chloropyridine-5-carboxamide
Product Categoriy of 6-Chloronicotinamide(6271-78-9): Pyridines ;Halopyridines ;Chloropyridines ;Halogenated Heterocycles ;blocks ;Heterocyclic Building Blocks

6-Chloronicotinamide Safety Profile

Hazard Note: Irritant
Hazard Codes:Xi

,Xn

Risk Statements:
20: Harmful by inhalation
21: Harmful in contact with skin
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements:
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection

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