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Cas Database |
| Name |
7-Benzyloxy-4-chloro-6-methoxy-quinoline |
EINECS | 1592732-453-0 |
| CAS No. | 286371-49-1 | Density | 1.262 |
| PSA | 31.35000 | LogP | 4.47580 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C17H14ClNO2 | Boiling Point | 434.8±40.0 °C(Predicted) |
| Molecular Weight | 299.757 | Flash Point | N/A |
| Transport Information | N/A | Appearance | N/A |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
7-(Benzyloxy)-4-chloro-6-methoxyquinoline;QC-2632;4-chloro-7-benzyloxy-6-methoxy-quinoline;4-chloro-6-methoxy-7-benzyloxyquinoline; |
Article Data | 15 |
7-Benzyloxy-4-chloro-6-methoxy-quinoline Synthetic route
- 205448-29-9, 849217-23-8
4-hydroxy-6-methoxy-7-benzyloxyquinoline
- 286371-49-1
7-(benzyloxy)-4-chloro-6-methoxyquinoline
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 7-benzyloxy-4-hydroxy-6-methoxyquinoline With trichlorophosphate for 2h; Heating / reflux; Stage #2: With sodium hydrogencarbonate; sodium carbonate In water at 20℃; pH=8; | 95% |
| With trichlorophosphate for 2h; Heating / reflux; | 95% |
| With trichlorophosphate In toluene at 120℃; for 1.5h; | 90% |
- 205448-31-3
4-chloro-6-methoxy-7-hydroxyquinoline
- 100-39-0
benzyl bromide
- 286371-49-1
7-(benzyloxy)-4-chloro-6-methoxyquinoline
Conditions
| Conditions | Yield |
|---|---|
| With potassium carbonate In N,N-dimethyl-formamide at 45℃; for 2h; | 95% |
- 205448-29-9, 849217-23-8
6-methoxy-7-benzyloxy-4(1H)-quinolinone
- 286371-49-1
7-(benzyloxy)-4-chloro-6-methoxyquinoline
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 6-methoxy-7-benzyloxy-4(1H)-quinolinone With trichlorophosphate at 110℃; for 3h; Stage #2: With sodium carbonate In chloroform; water Cooling with ice; | 94% |
| With sodium hydroxide; trichlorophosphate In chloroform | 21% |
| With trichlorophosphate In acetonitrile for 6h; Reflux; | 174.8 g |
- 75665-73-5
1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone
- 286371-49-1
7-(benzyloxy)-4-chloro-6-methoxyquinoline
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: sodium methylate / Dimethyl ether / 0.5 h / 20 °C 1.2: 8 h 2.1: trichlorophosphate / toluene / 2 h / Reflux View Scheme | |
| Multi-step reaction with 2 steps 1.1: sodium methylate / 1,2-dimethoxyethane / 0.5 h / Inert atmosphere 1.2: Inert atmosphere 2.1: trichlorophosphate / 10 h / Reflux View Scheme | |
| Multi-step reaction with 2 steps 1.1: sodium methylate / 1,2-dimethoxyethane / 0.5 h 1.2: 15 h / 20 °C 2.1: trichlorophosphate / 4.33 h / Cooling with ice; Reflux View Scheme |
- 100-39-0
benzyl bromide
- 286371-49-1
7-(benzyloxy)-4-chloro-6-methoxyquinoline
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 40 °C 2.1: nitric acid; sulfuric acid / dichloromethane / 1 h / 0 °C / pH 7 - 8 3.1: ammonium formate; iron / toluene; water / 103 °C 4.1: sodium methylate / Dimethyl ether / 0.5 h / 20 °C 4.2: 8 h 5.1: trichlorophosphate / toluene / 2 h / Reflux View Scheme | |
| Multi-step reaction with 5 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 40 °C 2.1: nitric acid; sulfuric acid / dichloromethane / 2.25 h / 0 °C 3.1: iron; ammonium acetate / toluene; water / 105 °C 4.1: sodium methylate / 1,2-dimethoxyethane / 0.5 h / Inert atmosphere 4.2: Inert atmosphere 5.1: trichlorophosphate / 10 h / Reflux View Scheme | |
| Multi-step reaction with 5 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C 1.2: 4 h / 20 °C 2.1: nitric acid / dichloromethane / 2 h / -20 - -10 °C 3.1: 5,5-dimethyl-1,3-cyclohexadiene / 15 h / Reflux 4.1: iron; acetic acid / 2 h / 60 - 90 °C 5.1: trichlorophosphate / acetonitrile / 6 h / Reflux View Scheme |
- 1835-11-6
4-benzyloxy-3-methoxyacetophenone
- 286371-49-1
7-(benzyloxy)-4-chloro-6-methoxyquinoline
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1.1: nitric acid; sulfuric acid / dichloromethane / 1 h / 0 °C / pH 7 - 8 2.1: ammonium formate; iron / toluene; water / 103 °C 3.1: sodium methylate / Dimethyl ether / 0.5 h / 20 °C 3.2: 8 h 4.1: trichlorophosphate / toluene / 2 h / Reflux View Scheme | |
| Multi-step reaction with 4 steps 1.1: nitric acid; sulfuric acid / dichloromethane / 2.25 h / 0 °C 2.1: iron; ammonium acetate / toluene; water / 105 °C 3.1: sodium methylate / 1,2-dimethoxyethane / 0.5 h / Inert atmosphere 3.2: Inert atmosphere 4.1: trichlorophosphate / 10 h / Reflux View Scheme | |
| Multi-step reaction with 4 steps 1: nitric acid / dichloromethane / 2 h / -20 - -10 °C 2: 5,5-dimethyl-1,3-cyclohexadiene / 15 h / Reflux 3: iron; acetic acid / 2 h / 60 - 90 °C 4: trichlorophosphate / acetonitrile / 6 h / Reflux View Scheme |
- 75665-88-2
1-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)ethanone
- 286371-49-1
7-(benzyloxy)-4-chloro-6-methoxyquinoline
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: ammonium formate; iron / toluene; water / 103 °C 2.1: sodium methylate / Dimethyl ether / 0.5 h / 20 °C 2.2: 8 h 3.1: trichlorophosphate / toluene / 2 h / Reflux View Scheme | |
| Multi-step reaction with 3 steps 1.1: iron; ammonium acetate / toluene; water / 105 °C 2.1: sodium methylate / 1,2-dimethoxyethane / 0.5 h / Inert atmosphere 2.2: Inert atmosphere 3.1: trichlorophosphate / 10 h / Reflux View Scheme | |
| Multi-step reaction with 3 steps 1: 5,5-dimethyl-1,3-cyclohexadiene / 15 h / Reflux 2: iron; acetic acid / 2 h / 60 - 90 °C 3: trichlorophosphate / acetonitrile / 6 h / Reflux View Scheme |
- 498-02-2
1-(3-methoxy-4-hydroxyphenyl)ethanone
- 286371-49-1
7-(benzyloxy)-4-chloro-6-methoxyquinoline
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 40 °C 2.1: nitric acid; sulfuric acid / dichloromethane / 1 h / 0 °C / pH 7 - 8 3.1: ammonium formate; iron / toluene; water / 103 °C 4.1: sodium methylate / Dimethyl ether / 0.5 h / 20 °C 4.2: 8 h 5.1: trichlorophosphate / toluene / 2 h / Reflux View Scheme | |
| Multi-step reaction with 5 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 40 °C 2.1: nitric acid; sulfuric acid / dichloromethane / 2.25 h / 0 °C 3.1: iron; ammonium acetate / toluene; water / 105 °C 4.1: sodium methylate / 1,2-dimethoxyethane / 0.5 h / Inert atmosphere 4.2: Inert atmosphere 5.1: trichlorophosphate / 10 h / Reflux View Scheme | |
| Multi-step reaction with 5 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C 1.2: 4 h / 20 °C 2.1: nitric acid / dichloromethane / 2 h / -20 - -10 °C 3.1: 5,5-dimethyl-1,3-cyclohexadiene / 15 h / Reflux 4.1: iron; acetic acid / 2 h / 60 - 90 °C 5.1: trichlorophosphate / acetonitrile / 6 h / Reflux View Scheme |
- 205448-28-8
5-{[(3-(benzyloxy)-4-methoxyphenyl)amino]methylene}-2,2-dimethyl-1,3-dioxane-4,6- dione
- 286371-49-1
7-(benzyloxy)-4-chloro-6-methoxyquinoline
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: biphenyl / diphenylether / 1 h / 220 °C / Inert atmosphere 2: trichlorophosphate / 5 h / Inert atmosphere; Reflux View Scheme | |
| Multi-step reaction with 2 steps 1: 1,2-dichloro-benzene / 7 h / 180 °C 2: trichlorophosphate / toluene / 1.5 h / 120 °C View Scheme | |
| Multi-step reaction with 2 steps 1: 1,2-dichloro-benzene / 7 h / 180 °C 2: trichlorophosphate / N,N-dimethyl-formamide / 1 h / 100 °C View Scheme |
- 286371-49-1
7-(benzyloxy)-4-chloro-6-methoxyquinoline
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: iron; acetic acid / 2 h / 60 - 90 °C 2: trichlorophosphate / acetonitrile / 6 h / Reflux View Scheme |
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