- Actinomycin
- ACTINOMYCIN 23-21
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- Actinomycin D, 7-bromo-(8CI)
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- Actinomycin V (8CI,9CI)
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| Name |
Actinomycin |
EINECS | N/A |
| CAS No. | 1402-38-6 | Density | N/A |
| PSA | 373.94000 | LogP | 2.63560 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C62H86N12O16 | Boiling Point | N/A |
| Molecular Weight | 0 | Flash Point | N/A |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by ingestion, intraperitoneal, subcutaneous and intravenous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Actinomycin; |
Actinomycin Chemical Properties
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IUPAC Name: 2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
Molecular Weight: 1255.41704 g/mol
Molecular Formula: C62H86N12O16
XLogP3-AA: 3.8
H-Bond Donor: 5
H-Bond Acceptor: 18
Rotatable Bond Count: 8
Tautomer Count: 64
Exact Mass: 1254.628475
MonoIsotopic Mass: 1254.628475
Topological Polar Surface Area: 356
Heavy Atom Count: 90
Complexity: 3030
Defined Atom StereoCenter Count: 4
Undefined Atom StereoCenter Count: 6
Canonical SMILES: CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)
C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
Isomeric SMILES: CC1C(C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C
(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C
InChIKey: RJURFGZVJUQBHK-QHYAFWOASA-N
Actinomycin History
The Actinomycin (CAS NO.1402-38-6) are a class of polypeptide antibiotics isolated from soil bacteria of the genus Streptomyces, of which the most significant is Actinomycin D. It was the first antibiotic isolated by Selman Waksman and his co-worker H. B. Woodruff in 1940.
Actinomycin Uses
Actinomycin D and its fluorescent derivative, 7-aminoactinomycin D (7-AAD), are used as stains in microscopy and flow cytometry applications. The affinity of these stains compounds for GC-rich regions of DNA strands makes them excellent markers for DNA. 7-AAD binds to single stranded DNA; therefore it is a useful tool in determining apoptosis and distinguishing between dead cells and live ones
Actinomycin Toxicity Data With Reference
| 1. | oms-omi 1250 µg/L | SOGEBZ Soviet Genetics. 4 (1968),100. | ||
| 2. | cyt-hmn:lym 200 µg/L/2H | CCPHDZ Cancer Chemotherapy and Pharmacology. 3 (1979),143. | ||
| 3. | orl-rat LDLo:1 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 74 (1942),25. | ||
| 4. | ipr-rat LDLo:1 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 74 (1942),25. | ||
| 5. | scu-rat LDLo:1 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 74 (1942),25. | ||
| 6. | ivn-rat LDLo:1 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 74 (1942),25. | ||
| 7. | orl-mus LDLo:10 mg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 74 (1942),25. | ||
| 8. | ipr-mus LDLo:1 mg/kg | TDKNAF Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. 14 (1955),60. | ||
| 9. | scu-mus LDLo:250 µg/kg | JPETAB Journal of Pharmacology and Experimental Therapeutics. 74 (1942),25. | ||
| 10. | ivn-mus LDLo:250 µg/kg | JPETAB Journal of Pharmacology an |
Actinomycin Safety Profile
Poison by ingestion, intraperitoneal, subcutaneous and intravenous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported.
Actinomycin Specification
Actinomycin (CAS NO.1402-38-6) is high toxic. It is flammable. So the storage environment of Actinomycin (CAS NO.1402-38-6) should be ventilate, low-temperature and dry.
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