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Bis(1-aziridinyl)(2-methyl-3-thiazolidinyl)phosphine oxide

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Name

Bis(1-aziridinyl)(2-methyl-3-thiazolidinyl)phosphine oxide

EINECS N/A
CAS No. 1078-79-1 Density 1.41g/cm3
PSA 61.44000 LogP 0.93420
Solubility N/A Melting Point N/A
Formula C8H16 N3 O P S Boiling Point 382.4°C at 760 mmHg
Molecular Weight 233.274 Flash Point 185.1°C
Transport Information N/A Appearance N/A
Safety Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of SOx, POx, and NOx. Risk Codes N/A
Molecular Structure Molecular Structure of 1078-79-1 (Imiphos) Hazard Symbols N/A
Synonyms

Phosphineoxide, bis(1-aziridinyl)(2-methyl-3-thiazolidinyl)- (7CI,8CI); IE-35; Imifos;Imiphos; Marcophan; Marcophane; Markofane

 

Bis(1-aziridinyl)(2-methyl-3-thiazolidinyl)phosphine oxide Chemical Properties

IUPAC Name: 3-[bis(aziridin-1-yl)phosphoryl]-2-methyl-1,3-thiazolidine
Synonyms of Bis(1-aziridinyl)(2-methyl-3-thiazolidinyl)phosphine oxide (CAS NO.1078-79-1): Imiphos ; BRN 1214283 ; Imiphos ; Marcophan ; Marcophane ; Markofane ; 3-(Bis(1-aziridinyl)phosphinyl)-2-methylthiazolidine ; Phosphine oxide, bis(1-aziridinyl)(2-methyl-3-thiazolidinyl)-
CAS NO: 1078-79-1
Molecular Formula of Bis(1-aziridinyl)(2-methyl-3-thiazolidinyl)phosphine oxide (CAS NO.1078-79-1): C8H16N3OPS
Molecular Weight: 233.2709 
H bond acceptors: 4
H bond donors: 0
Freely Rotating Bonds: 3
Polar Surface Area: 61.44 Å2
Index of Refraction: 1.637
Molar Refractivity: 59.33 cm3
Molar Volume: 165.2 cm3
Surface Tension: 61.4 dyne/cm
Density of Bis(1-aziridinyl)(2-methyl-3-thiazolidinyl)phosphine oxide (CAS NO.1078-79-1): 1.41 g/cm3
Flash Point: 185.1 °C
Enthalpy of Vaporization: 63.08 kJ/mol
Boiling Point: 382.4 °C at 760 mmHg
Vapour Pressure: 4.72E-06 mmHg at 25°C
Molecular Structure:

Bis(1-aziridinyl)(2-methyl-3-thiazolidinyl)phosphine oxide Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 142mg/kg (142mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
"Imifos," Giller, S.A., ed., Izd, Riga, USSR, 1968Vol. -, Pg. 129, 1968.
mouse LD50 oral 225mg/kg (225mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
"Imifos," Giller, S.A., ed., Izd, Riga, USSR, 1968Vol. -, Pg. 129, 1968.
rat LD50 intraperitoneal 18700ug/kg (18.7mg/kg) BLOOD: LEUKOPENIA Farmakologiya i Toksikologiya Vol. 37, Pg. 464, 1974.

Bis(1-aziridinyl)(2-methyl-3-thiazolidinyl)phosphine oxide Safety Profile

Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of SOx, POx, and NOx.

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