- Synthesis and mutagenicity of a new mutagen, 2-amino-1,7,9- trimethylimidazo-[4,5-g]quinoxaline, and its analog
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A new mutagen, 2-amino-1,7,9-trimethylimidazo-[4,5-g]quinoxaline (1), isolated from beef extract, was synthesized from 3-fluoro-2-methylaniline via an intermediate, 2,8-dimethyl-7-methylaminoquinoxaline (7a). Its 2- methylanalog (2) was also synthesized from the same intermediate. The synthetic 1 showed the same mutagenic activity as the isolated mutagen. However, 2 was non-mutagenic.
- Achiwa,Shiozawa,Nukaya,Terao
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p. 408 - 409
(2007/10/02)
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- Synthesis of the potent mutagen 3,5,8-trimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine.
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The mutagenic title compound (5,8-DiMeIQx) was synthesized by two different routes: from 2-methyl-4,6-dinitroaniline; and from 4-chloro-2-methyl-6-nitroaniline. The latter and more convenient route involved 2,1,3-benzoselenadiazole intermediates.
- Nyhammar,Grivas
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p. 583 - 587
(2007/10/02)
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