Synthesis of the potent mutagen 3,5,8-trimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine.
The mutagenic title compound (5,8-DiMeIQx) was synthesized by two different routes: from 2-methyl-4,6-dinitroaniline; and from 4-chloro-2-methyl-6-nitroaniline. The latter and more convenient route involved 2,1,3-benzoselenadiazole intermediates.
Nyhammar,Grivas
p. 583 - 587
(2007/10/02)
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