cas 103766-25-2, Gimeracil | Articles data

Articles about 103766-25-2Total 6 be found

CONVENIENT AND PRACTICAL SYNTHESIS OF 5-CHLORO-4-HYDROXY-2(1H)-PYRIDINONE
5-Chloro-4-hydroxy-2(1H)-pyridinone (1) was prepared by 4-step reactions via the key intermediate 5-chloro-3-cyano-4-methoxy-2(1H)-pyridinone (5).This synthetic route has several advantages over the reported methods in procedure, yield and applicability.
Yano, Shin-go,Ohno, Tomoyasu,Ogawa, Kazuo
p. 145 - 148
(1993)
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Halo hydroxy aromatic compound,
3, 5 - Dichloropyridine - 2, 4 - dihalo-aromatic compound used as a raw material [to] diol while solving various problems caused by, such as halo hydroxy aromatic compound can be produced in low cost manufacture of the dihalo-aromatic compound [gimerashiru[gimerashiru], halo hydroxy aromatic compound useful as a raw material in the manufacture of the foregoing method for producing a compound, said halo hydroxy aromatic compound useful as a raw material of the composition. Such halo hydroxy aromatic compound production [solution] [gimerashiru[gimerashiru], halo tri halo hydroxy aromatic compound by reduction of specific cyclic compound is produced. [Drawing] no
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Paragraph 0045

(2021/10/13)

A convenient synthesis of gimeracil
A practical three-step synthetic approach to gimeracil in a 68% overall yield is described, using 2,4-dimethoxypyridine as the starting material with 3,5-dichloro-2,4-dimethoxypyridine and 3,5-dichloro-2,4-dihydroxypyridine as intermediates. The advantages of this procedure include short reaction steps, simple operation and good yield.
Li, Xiao-Lin,Zhu, Hao-Ting,Zhan, Li,Liu, Ting,Cheng, Guang,Liu, Ning,Yu, Shan-Bao,Li, Hui,Luo, Yu,Yang, Fan,Tang, Jie
p. 33 - 34
(2018/02/28)

A lucky US pyrimidine of the composition and its preparation method
The invention provides a gimeracil composition, a preparation method of gimeracil analogues such as 1-methyl-4-hydroxyl-5-chloro-2-(1H) pyridine, 4-methoxy-5-chloro-2-(1H) pyridine and 3-cyano-4-hydroxyl-5-chloro-2-(1H) pyridine, and application of the analogues in research on quality control of gimeracil.
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Paragraph 0025; 0041; 0042; 0043; 0044; 0045

(2017/08/02)

A lucky US pyrimidine synthesis method (by machine translation)
The invention belongs to the technical field of chemical synthesis, in particular to a lucky US pyrimidine synthesis method. The method will be the 3 - cyano - 4 - methoxy - 2 - H - pyridone with sulfonic acid chloride in glacial acetic acid in the separated after the reaction to the 3 - cyano - 4 - methoxy - 5 - chloro 2 - (1H) pyridone; the 3 - cyano - 4 - methoxy - 5 - chloro 2 - (1H) pyridone with hydrobromic acid to obtain lucky US pyrimidine. The invention provides a method for the preparation of pyrimidine lucky US, simple operation, cycle is short, low cost, good product purity, easy product of large-scale production. (by machine translation)
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Paragraph 0023; 0024; 0026; 0027; 0028

(2017/07/01)

PROCESS FOR PRODUCTION OF 5-CHLORO-2,4-DIHYDROXYPYRIDINE
To provide an industrially advantageous process for producing 5-chloro-2,4-dihydroxypyridine, which is an inhibitor acting on a biodegradation enzyme that biodegrades an anti-malignant-tumor agent 5-fluorouracil. The process is carried out under mild conditions with a small number of steps and produces less industrial waste. The process employs a 5-chloro-1,3-dioxin-4-one derivative (2) as a starting substance to thereby form a pyrone derivative (4) represented by formula (4): (wherein R3 and R4, which are identical to or different from each other, each represent a C1 to C6 linear-chain or branched-chain alkyl group, or a silyl group having a C1 to C6 linear-chain or branched-chain alkyl group), and subsequently, 5-chloro-2,4-dihydroxypyridine (1) is produced from the pyron derivative.
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Page/Page column 9

(2008/06/13)