- Perylenophthalocyanines
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The first perylenophthalocyanines have been synthesised using a Diels-Alder reaction between dialkylperylenes and fumaronitrile as the key step towards the dinitrile precursors. As expected the octaalkylperylenophthalocyanines show red-shifted absorption spectra. They are high melting solids that do not display mesophase behaviour at accessible temperatures. A 3:1 phthalocyanine/ perylenophthalocyanine hybrid material, prepared by a mixed macrocyclisation reaction, presents an unusual board-like molecular profile. Its absorption maxima lie between those observed for the parent phthalocyanines and the symmetrical perylenophthalocyanines. The spectrum shows a characteristic split Q-band due to the reduced symmetry of the core. This material is non-mesogenic but is sufficiently soluble to permit processing and characterisation. The 1H NMR spectrum indicates that at least two of the appended alkyl chains are displaced out of the macrocycle plane and lie in its shielding region - an arrangement that disfavours the face-to-face packing required for mesophase formation.
- Cammidge, Andrew N.,Gopee, Hemant
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- Methylterrylene isomers
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2-Methyl and 3-methylterrylenes have been obtained by Suzuki coupling of 3-bromoperylene and corresponding methylnaphthylboronic acids or esters, giving methylnaphthylperylene isomers, followed by Scholl cyclodehydrogenation; the latter reaction gave also the other cyclodehydrogenation isomers 10- (respectively, 9-) methylbenzo[4,5]indeno[1,2,3-cd]perylene.
- Nagarajan, Samuthira,Barthes, Cecile,Girdhar, Navdeep K.,Dang, Tung T.,Gourdon, Andre
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- Thiophene derivatives used as inhibitor of URAT1
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The invention relates to thiophene derivatives used as an inhibitor of urate transporter 1 (URAT1), in particular relates to the thiophene derivatives represented by a general formula (I) shown in thedescription, a pharmaceutically-acceptable salt of the thiophene derivatives, and preparation methods of the thiophene derivatives and the pharmaceutically-acceptable salt, and particularly relates to an application of the thiophene derivatives and the pharmaceutically-acceptable salt used as a therapeutic agent for a disease associated with an abnormal uric acid level.
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Paragraph 0142; 0144; 0145; 0146
(2019/04/26)
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- Composite taken as URAT 1 inhibitor
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The invention provides a series of composite with a formula (I), wherein n is selected from 1, 2 or 3, X is selected from O or S, Q is selected from C or N, and R is selected from H, halogen or -C1-6.The composite can be used as the URAT 1 inhibitor and can be used for treating hyperuricemia and gout.
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- ROCK inhibitor containing methylnaphthalene and propylene glycol thiophene amide
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The invention belongs to the technical field of medicine. In particular, the invention relates to a compound containing a methylnaphthalene and propylene glycol thiophene amide structure and capable of serving as a ROCK inhibitor, a preparation method thereof and application thereof to preparation of medicines for treating sexual dysfunction, inflammatory diseases, ophthalmic diseases, respiratorysystem diseases and the like. (The formula is as shown in the description).
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Paragraph 0042; 0045; 0046
(2018/05/16)
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- ROCK inhibitor comprising methylnaphthalene and propanediol thiophene amide structure
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The invention belongs to the technical field of medicines and particularly relates to a compound comprising methylnaphthalene and a propanediol thiophene amide structure, a preparation method of the compound, and application of the compound to preparation of medicines for treating sexual dysfunction, inflammatory diseases, eye diseases and diseases of the respiratory system, and the compound can serve as a ROCK inhibitor.
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Paragraph 0041; 0042; 0045; 0046
(2018/07/06)
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- ROCK inhibitor containing methylnaphthalene and nitrile thiophene amide structures and application
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The invention belongs to the technical field of medicine, in particular to a compound containing methylnaphthalene and nitrile thiophene amide structure, which can serve as a ROCK inhibitor, a preparation method thereof, and application thereof to preparation of medicine for treating sexual dysfunction, inflammatory diseases, ophthalmic diseases and respiratory system diseases.
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Paragraph 0042; 0045; 0046
(2018/07/30)
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- Alkoxythiophene amide and methylnaphthalene structure containing compounds and preparation method and application thereof
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The invention belongs to the technical field of medicines, and particularly relates to a class of alkoxythiophene amide and methylnaphthalene structure containing compounds, a preparation method thereof and application thereof to preparation of medicines for treating sexual dysfunction, inflammatory diseases, ophthalmic diseases, respiratory system diseases and the like. In a general formula, R isselected from C1-C5 alkyl groups.
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Paragraph 0044; 0045; 0048-0049; 0058-0059
(2018/07/06)
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- 2-aminopyridines containing fused ring substituents
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The present invention relates to 2-aminopyridine derivatives of the formula wherein G, R1 and R2 are defined as in the specification, that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and to their use in the treatment and prevention of central nervous system and other disorders.
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- Methylterrylene isomers
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2-Methyl and 3-methylterrylenes have been obtained by Suzuki coupling of 3-bromoperylene and corresponding methylnaphthylboronic acids or esters, giving methylnaphthylperylene isomers, followed by Scholl cyclodehydrogenation; the latter reaction gave also the other cyclodehydrogenation isomers 10- (respectively, 9-) methylbenzo[4,5]indeno[1,2,3-cd]perylene.
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