- Pd-Catalyzed Tandem Cyclization via C-H Arylation and Acylation for the Construction of Polycyclic Scaffolds
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The first Pd-catalyzed tandem cyclization of imidazo[1,2-a]pyridines with 2-chlorobenzaldehydes through C-H arylation and acylation is presented for the efficient synthesis of novel 6H-benzo[b]imidazo[5,1,2-de]quinolizin-6-ones. The direct acylation react
- Mu, Bing,Li, Jingya,Zou, Dapeng,Wu, Yusheng,Chang, Junbiao,Wu, Yangjie
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- Cardiotonic agents. 1. Novel 8-aryl-substituted imidazo[1,2-a]- and -[1,5-a]pyridines and imidazo[1,5-a]pyridinones as potential positive inotropic agents
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Several 8-arylimidazo[1,2-a]pyridines, 8-arylimidazo[1,5-a]pyridines, and 8-arylimidazo[1,5-a]pyridinones were prepared and tested in vitro for potential cardiac inotropic and electrophysiological activity. Selected analogues were further tested in vivo i
- Davey,Erhardt,Lumma Jr.,Wiggins,Sullivan,Pang,Cantor
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p. 1337 - 1342
(2007/10/02)
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- Imidazo[1,2-a]pyridines, and process for their preparation
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This invention relates to novel substituted imidazo[1,2-a]pyridines, most especially novel 8-phenylimidazo[1,2-a]pyridines and a process for their preparation. The compounds of the invention have been found to have cardiotonic antiarrhythmic, CNS stimulant, CNS depressant and other pharmacological effects.
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