Stereoselective synthesis of substituted pyrrolidines
The present invention relates to a halo-lactonization process for the stereoselective preparation of protected 1-(halo-methyl)-3-oxo-2-oxa-5-azabicyclo[2.2.1]heptane derivatives of formula (II) wherein Hal and R1 are as defined in the description. The invention further relates to the novel compounds of formula (II), and to their further transformation to the compounds of formula (III) wherein R1, R2, R3, and R4 are as defined in the description.
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Paragraph 0053
(2015/07/02)
Copper-catalyzed tandem oxidation-olefination process
A novel catalytic sequence aerobic oxidation-olefination has been developed. A single and inexpensive copper catalyst provides a large range of olefins from alcohols in good to excellent yields. The reaction exhibits excellent functional group compatibili
Davi, Michael,Lebel, Helene
supporting information; experimental part
p. 41 - 44
(2009/07/11)
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