1094039-81-2Relevant articles and documents
Stereoselective synthesis of substituted pyrrolidines
-
Paragraph 0053, (2015/07/02)
The present invention relates to a halo-lactonization process for the stereoselective preparation of protected 1-(halo-methyl)-3-oxo-2-oxa-5-azabicyclo[2.2.1]heptane derivatives of formula (II) wherein Hal and R1 are as defined in the description. The invention further relates to the novel compounds of formula (II), and to their further transformation to the compounds of formula (III) wherein R1, R2, R3, and R4 are as defined in the description.