- Chlorpheniramine maleate crystal form preparation method
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The invention discloses a chlorpheniramine maleate crystal form preparation method which is different from an existing crystal form preparation method, wherein two solvents are used in the crystallization process, the impurity content in a finished product is effectively reduced, the yield and the purity are improved, the crystal form is stable, the crystal form cannot be changed due to the change of the solvent proportion, and industrial production is facilitated.
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Paragraph 0023-0031
(2021/12/07)
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- 1/10-water maleic acid chlorpheniramine compound and pharmaceutical composition thereof (by machine translation)
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The invention discloses-water 1/10 maleic acid chlorphenamine maleate compound and a preparation method thereof, wherein the compound is measured by a powder X-2 θ ± 0.2° ray diffraction method and shows characteristic 12.4 ° diffraction peaks 18.9 ° 13.1 ° at 20.3 ° 19.4 ° diffraction 21.6 ° 22.0 ° angles in 24.2 ° 24.7 °, 25.1 ° 26.3 ° and 30.1 ° 32.3 °. 1/10 Water prepared by the method has the advantages of good stability, high purity, good solubility and high bioavailability of the preparation, and is simple in process, high in yield, high in repeatability and suitable for industrial production. (by machine translation)
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- Chlorpheniramine maleate salifying substance and synthesis method and application thereof
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The invention provides a chlorpheniramine maleate salifying substance and a synthesis method and application thereof. The synthesis method comprises the following steps: weighing the following raw material components in parts by weight: 80-90 parts of maleic acid, 460-530 parts of absolute ethyl alcohol, 190-210 parts of chlorpheniramine hydrolysate, 4-10 parts of activated carbon and the like, then stirring and mixing the weighed raw material components to obtain a preheated mixture, transferring the preheated mixture into a filter pressing kettle, carrying out filter pressing and purification to obtain a filter pressing feed liquid of a crystallization kettle, cooling the filter pressing feed liquid of the crystallization kettle, carrying out centrifugal filtration, flushing by absoluteethyl alcohol after filtration, carrying out centrifugation again to obtain the chlorpheniramine maleate salifying substance. By adopting the synthesis method disclosed by the invention, the purity and the final yield of the synthesized chlorpheniramine maleate salifying substance are improved, and the impurity content of the chlorpheniramine maleate salifying substance is reduced.
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Paragraph 0024-0035
(2020/08/25)
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- Chlorpheniramine maleate as well as preparation method and application thereof
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The invention provides chlorpheniramine maleate as well as a preparation method and application thereof. The preparation method comprises the following steps: stirring and mixing chlorpheniramine hydrolysate, absolute ethyl alcohol, maleic acid and activated carbon, then heating the mixture to a reflux state, keeping the temperature for 1-2 hours in the reflux state, and then carrying out filter pressing, purification, recrystallization, centrifugation, vacuum drying and the like processes to obtain the chlorpheniramine maleate. The chlorpheniramine maleate obtained by the preparation method disclosed by the invention has the advantages of higher purity, no solvent residue and mild reaction conditions, and is easy for industrial production.
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Paragraph 0030-0044
(2020/08/17)
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- A new method for synthesizing of chlorpheniramine maleate (by machine translation)
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The invention belongs to the field of organic synthesis of the drug, in particular to a new synthetic method of chlorpheniramine maleate. The invention comprises the following sequence of steps: (1) under acidic conditions, to [...] in cobalt catalyst, in the presence of a [...] and 2 - halo pyridine react, generating 2 - to the benzylic pyridine; (2) 2 - to the benzylic pyridine in under the action of the sodium amide and N, N - dimethyl base halogen ethane reaction, generating the cream, chlorpheniramine and maleic acid and get chlorpheniramine maleate. The method of reaction steps is relatively short, the raw material is cheap, the process is simple, easy to operate, does not need special reaction conditions, therefore is more suitable for industrial production. (by machine translation)
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- Novel synthetic method for chlorpheniramine maleate
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The invention belongs to the field of medicinal chemistry, and specifically relates to a synthetic method for chlorphenamine maleate. The method provided by the invention comprises the following steps in sequence: (1) allowing p-cyanobenzylchloride to react with acetylene under the catalysis of a catalyst namely cobaltocene so as to generate p-chlorobenzyl pyridine; and (2) allowing p-chlorobenzyl pyridine to react with N,N-dimethyl chloroethane under the catalysis of sodium amide so as to generate chlorpheniramine, and subjecting chlorpheniramine and maleic acid to a neutralization reaction so as to generate chlorpheniramine maleate.
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Paragraph 0018; 0019
(2017/07/19)
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- Manufacture of hollow fine tubular drug delivery systems
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Pharmaceutical compositions are provided which contain hollow fine tube drug delivery systems. The compositions comprise a pharmaceutically suitable carrier, preferably in the form of a capsule, tablet, suspension, or suppository, and at least one drug delivery system which consists essentially of (1) a polymeric tube having a membrane outer sheath and a hollow core, and (2) at least one drug compound contained within the core, said system contained in the composition in an amount sufficient to deliver a therapeutic amount of the drug contained therein at a predetermined rate over a predetermined period of time. By varying the polymer, the permeability of the outer sheath, the drug, the drug concentration in the hollow core of the tube, the tube diameter, the tube length, the tube core diameter, and the sealing of the tube ends, a wide variety of drug therapeutic amounts, rates and dosing times can be achieved.
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- Pharmaceutical compositions containing hollow fine tubular drug delivery systems
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Pharmaceutical compositions are provided which contain hollow fine tube drug delivery systems. The compositions comprise a pharmaceutically suitable carrier, preferably in the form of a capsule, tablet, suspension, or suppository, and at least one drug delivery system which consists essentially of (1) a polymeric tube having a membrane outer sheath and a hollow core, and (2) at least one drug compound contained within the core, said system contained in the composition in an amount sufficient to deliver a therapeutic amount of the drug contained therein at a predetermined rate over a predetermined period of time. By varying the polymer, the permeability of the outer sheath, the drug, the drug concentration in the hollow core of the tube, the tube diameter, the tube length, the tube core diameter, and the sealing of the tube ends, a wide variety of drug therapeutic amounts, rates and dosing times can be achieved.
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