Lewis Acid-Catalyzed Rearrangement of Fluoroalkylated Propargylic Alcohols: An Alternative Approach to β-Fluoroalkyl-α,β-enones
A practical Lewis acid-catalyzed Meyer-Schuster rearrangement of fluoroalkylated propargylic alcohols, leading to a series of β-fluoroalkyl-α,β-enones, is developed. The methodology reported herein features moderate to high yields and high stereoselectivi
Addition of Organocuprates to Acetylenic Di- and Trifluoromethyl Ketones. Regiospecific Synthesis of β,β-Disubstituted Unsaturated Fluoro ketones
A regiospecific synthesis of β,β-disubstituted-α,β-unsaturated di- and trifluoromethyl ketones has been achieved by the conjugate addition of higher order cyano cuprate reagents to acetylenic di- and trifluoromethyl ketones.An efficient and reproducible s
Lindermann, Russel J.,Lonikar, Madhu S.
p. 6013 - 6022
(2007/10/02)
THE SYNTHESIS OF UNSATURATED TRIFLUOROMETHYL KETONES BY REGIOSELECTIVE ORGANOCUPRATE ADDITION TO ACETYLENIC TRIFLUOROMETHYL KETONES
Regiospecific and stereoselective synthesis of unsaturated trifluoromethyl ketones has been accomplished by the addition of higher order cyano cuprates to acetylenic trifluoromethyl ketones.
Linderman, Russel J.,Lonikar, Madhu S.
p. 5271 - 5274
(2007/10/02)
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