Diastereoselective Construction of α-Quaternary Carbon Centers in the Chiral-Auxiliary-Mediated Aza-Claisen Rearrangement of Ketene N-Allyl-N,O-acetals
The aza-Claisen rearrangement of ketene N-allyl-N,O-acetals has been applied to the diastereoselective construction of precursors of 2-quaternary 4-pentenoic acids (82-97percent ds).Best yields are obtained when alkoxides are used to deprotonate the intermediate oxazolinium salts.
Kurth, Mark J.,Brown, Edward G.
p. 362 - 366
(2007/10/02)
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