- New Synthesis of Optically Active 5-Isoxazolidinones and β-Amino Acids
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A new simple and stereoselective synthesis of 5-isoxazolidinones based on the reaction of lithiated 2-isopropyl-2-oxazolines with nitrones is described. A chiral version of such a methodology allows the preparation of highly enantioenriched 5-isoxazolidinones which are useful precursors for the synthesis of β-amino acids.
- Luisi, Renzo,Capriati, Vito,Florio, Saverio,Vista, Teresa
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p. 9861 - 9864
(2007/10/03)
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- Alkyl Nitrate Nitration of Active Methylene Compounds. Nitration of 2-Substituted 2-Oxazolines
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2-Alkyl- and 2-aralkyl-2-oxazolines are readily converted to the corresponding α-nitroalkyl- and α-nitroaralkyl-2-oxazolines an treatment with an alkali metal amide such as potassium or sodium amide in liquid ammonia or with lithium diisopropylamide (LDA)
- Feuer, Henry,Bevinakatti, Hanamanthsa S.,Luo, Xuan-Gan
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p. 825 - 832
(2007/10/02)
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- SYNTHESIS OF ISOTHIOCYANATES FROM NON-AROMATIC NITROGEN-CONTAINING HETEROCYCLES
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Investigation of the reaction of thiophosgene with Δ2-oxazolines I, Δ3-thiazolines II, 4H-benzothiazines III, 2-methoxypentahydro-Δ1-azepine IV, theophylline and caffeine showed that only compounds I and IV reacted to give 2-acyloxyethyl isothiocyanates and methyl 6-isothiocyanatohexanoate.The structure of these products was corroborated by IR, 1H NMR, 13C NMR and mass spectral methods.The suitability of the above-mentioned compounds to react is discussed.
- Gonda, Jozef,Kristian, Pavol,Mikler, Lubomir
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p. 112 - 117
(2007/10/02)
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- Allenes. Part 44. Formation of Oxazolines and Benzoxazoles from Allenic nitriles and amides and from Phenylpropynenitrile.
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Michael addition of ethanolamines and 2-aminophenol to allenic nitriles, allenic amides and phenylpropynenitrile gives enaminic nitriles and amides which at 290 deg - 320 deg yield oxazolines and benzoxazoles.
- Fomum, Z. Tanee,Nkengfack, A. Ephrem,Mpango, George W. P.,Landor, Stephen R.,Landor, Phyllis D.
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p. 901 - 924
(2007/10/02)
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