- 3,9-DIAZASPIRO[5.5]UNDECANE COMPOUNDS
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The present invention covers 3,9-diazaspiro[5.5]undecane compounds of general formula (I) and general formula (I-a), in which R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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Page/Page column 338
(2020/04/09)
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- Synthesis of trifluoromethyl- A nd ester group-substituted α-carbolines via iron-catalyzed tandem cyclization reaction
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An efficient approach to prepare trifluoromethyl-α-carbolines and ester group-substituted α-carbolines via the tandem cyclization reaction of 2-(2-aminophenyl)acetonitriles and trifluoromethyl 1,3-diones or ,?-unsaturated α-ketoesters was reported. The tr
- Xu, Yumin,Chen, Xiaoqian,Gao, Yiqin,Yan, Zicong,Wan, Changfeng,Liu, Jin-Biao,Wang, Zhiyong
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p. 4354 - 4364
(2020/04/10)
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- Synihesis of 3-substituied indoles via a modified madeling reaction
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Anilides 4a-c,e-k, lla-d in which the amide function is benzylated, or silylated and having different electron-withdrawing groups (EWG) at the methyl methyl in the ortho position of the amide function, cyclize under the influence of potassium tert-butoxide to the corresponding indole derivatives 5a-c,e-k and 9a-d, respectively, under these conditions the chloroacetamides 4d,n and 11e are converted into the tetrahydroquinolines 6a,b and 12, respectively. Treatment of chloroacetamide 4m with KOt-Bu gave, in addition to starting material, indole 5m, tetrahydroquinoline 6c and 2(1H)-quinolinone 7. When 3-indolecarbonitrile 5a is treated with sodium in liquid amnonia debenzylation takes place, while after catalytic hydrogenation with 5% Pd/C the corresponding 2,3-dirnethylindole 8 is formed.
- Orlemans,Schreunder,Conti,Verboom,Reinhoudt
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p. 3817 - 3826
(2007/10/02)
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