- A convenient conversion of substituted cyclohexenones into aryl methyl ketones
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This work describes a straightforward multistep conversion of substrates containing a cyclohexenone moiety into mono-, bi- and tricyclic aryl methyl ketones in one single working process. Crucial steps are the addition of 1-ethoxyvinyllithium to the carbonyl group, followed by acid-catalyzed enol ether hydrolysis, dehydration, and dehydrogenation. Georg Thieme Verlag Stuttgart · New York.
- Gehring, Andrep.,Bracher, Franz
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- Catalytic Friedel-Crafts acylation and benzoylation of aromatic compounds using activated hematite as a novel heterogeneous catalyst
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Catalytic Friedel-Crafts acylation of benzene and unactivated benzenes such as chlorobenzene and nitrobenzene have been successfully carried out using activated hematite (α-Fe2O3) as a new, heterogeneous and green catalyst. Sonication of neat α-Fe2O3 in a water bath under air atmosphere at room temperature followed by heating at 200°C, dramatically increase the activity of α-Fe2O 3. With the catalyst loading as low as 5.0mol%, a wide variety of benzene derivatives were easily converted into the corresponding acylated products in a clean and high-yielding acylation reaction. It was found that the activated α-Fe2O3 could be efficiently recycled and reused several times by simple washing with ethyl acetate, this cannot be attained with most of the traditional catalysts. Copyright
- Sharghi, Hashem,Jokar, Mahboubeh,Doroodmand, Mohammad Mahdi,Khalifeh, Reza
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experimental part
p. 3031 - 3044
(2011/02/21)
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- Process for the production of isosolanone and solanone, intermediates useful in said process and organoleptic uses of said intermediates
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Described is a novel genus of compounds defined according to the structure: STR1 wherein Z represents hydrogen, MgX and the moiety having the structure: STR2 and X represents chlor, bromo, or iodo; as well as 5-isopropyl-8-methyl-5,8-nonadien-2-one; uses of same as intermediates in a process for producing isosolanone and solanone; and organoleptic uses of 5-isopropyl-8-methyl-5,8-nonadien-2-one and 2,6-dimethyl-5-methylene-1-hepten-4-ol. The novel process of our invention involved the steps of: (i) formation of the compound having the structure: STR3 by means of reacting 3-methyl-2-methylenebutanal with the compound having the structure: STR4 (ii) acid hydrolysis of the resulting compound in order to form 2,6-dimethyl-5-methylene-1-heptene-4-ol; (iii) reaction of 2,6-dimethyl-5-methylene-1-hepten-4-ol with methyl aceto acetate in order to form 2,6-dimethyl-5-methylene-1-hepten-4-yl aceto acetate or, directly, 5-isopropyl-8-methyl-5,8-nonadiene-2-one; (iv) reacting 2,6-dimethyl-5-methylene-1-hepten-4-yl aceto acetate in the presence of an appropriate catalyst to form the 5-isopropyl-8-methyl-5,8-nonadiene-2-one; and (v) isomerizing the 5-isopropyl-8-methyl-5,8-nonadien-2-one in order to form a mixture of solanone and the isosolanone or 5-isopropyl-8-methyl-5,8-nonadiene-2-one.
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- Some Novel Rearrangements of Monoterpenes with NBS/DMF Reagent
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Some novel oxidation products have been obtained during the reaction of citronellol (1), car-3-ene (5), 4-acetyl-car-2-ene and piperitone with N-bromosuccinimide in basic medium.Such products have not been reported earlier under the conditions used.
- Agarwal, V. K.,Sethi, V. K.,Thappa, R. K.,Agarwal, S. G.,Dhar, K. L.
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p. 996 - 998
(2007/10/02)
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