- The preparation method of N, N - diisopropylethylenediamine. Preparation method of
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N, N -isopropyl N chloroethylamine hydrochloride and the urotropine are reacted in an organic solvent to obtain N - and N diisopropyltripropylestamine quaternary ammonium salt; and the method comprises the following steps: N - reacting with the urotropine in an organic solvent to obtain the quaternary ammonium salt.2 - N - N. N, N - Diisopropyltriprolol quaternary ammonium salt and concentrated hydrochloric acid were reacted in an organic solvent to give N, N - diisopropylethylamine. To the preparation method, safety risks caused by high-pressure production routes are avoided, the quality risks caused by dimer impurities are avoided, environmental pollution is avoided, raw materials are economical and easy to obtain, production cost is low, and good economic benefits are achieved.
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Paragraph 0055; 0123-0129; 0138-0151
(2021/08/25)
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- Synthesizing method of N,N-diisoprylamino ethylamine
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The invention discloses a synthesizing method of N,N-diisoprylamino ethylamine. The synthesizing method comprises the following steps of using diisopropylamine and chloroacetonitrile as initial raw materials, and performing aminolysis reaction and reduction reaction, so as to synthesize the N,N-diisoprylamino ethylamine. The synthesizing method has the advantages that the technology route is advanced, the technology condition is reasonable, the cost of raw materials is low, the obtaining is easy, the reaction condition is mild, the operation is simple and safe, the atom economy is high, the production cost is low, the amount of three wastes (waste gas, waste water and industrial residue) is small, the synthesizing method is suitable for industrialized production, and the larger implementing value and social and economical benefits are realized.
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Paragraph 0042; 0044; 0046-0048; 0050; 0052
(2017/10/22)
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- A sulfuric acid west pula Tanzania method for the preparation of
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The invention relates to a preparation method of Pramiracetam sulfate. The preparation method comprises the steps of using N, N-diisopropylethanolamine as a starting raw material, and conducting chlorination and ammonolysis to obtain an intermediate N, N- diisopropylethylene diamine; then conducting acylation, substitution, salt forming and refining to obtain the Pramiracetam sulfate. The preparation method of the Pramiracetam sulfate has the characteristics that the reaction process is safe and controllable, the cost of used raw materials and solvent is low and the raw materials and the solvent are easy to obtain; organic solvent is very easy to recycle, the emission of organic matters is greatly reduced, and the environmental friendliness is improved; since the intermediate N-[(2-diisopropyl amino) ethyl]-chloroacetamide is not separated and purified, the reaction equipment is simplified, and the operation process is enabled to be more high-efficient.
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Paragraph 0016; 0046; 0047
(2016/10/09)
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- Synthesis and characterization of N-substitutional ethylenediamine derivatives
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N-Substituted and N,N-disubstituted ethylenediamine derivatives were prepared rapidly in aqueous conditions from 30 to 76 % yields, respectively, on a multi-gram scale starting from inexpensive and commercially available starting materials. The steps involved Michael addition, hydrazinolysis and Curtius rearrangements. The highlight of this method lies on its convenience and economy in accessing these intermediates.
- Yao, Ri-Sheng,Jiang, Lai-En,Wu, Sheng-Hua,Deng, Sheng-Song,Yang, Yang
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p. 3792 - 3794
(2012/01/05)
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- Compounds for the treatment of urinary incontinence
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The invention concerns compounds having the formula I STR1 wherein Ar is a phenyl or benzyl group which is optionally substituted with hydroxy or alkoxy;R 1 is hydrogen, lower alkyl, lower alkoxy, hydroxy;R 2 is hydrogen, lower alkyl;R 3 is NR 4 R 5, whereinR 4 and R 5 which can be the same or different, are lower alkyl, or wherein R 4 and R 5, when taken together, form a ring with the nitrogen atom, whereby said ring optionally is substituted with lower alkyl;n is 0 or 1;m is 2 or 3 andtheir salts with physiologically acceptable acids and when the compounds can be in form of optical isomers, the racemic mixture and the individual isomers, for the treatment of disorders of the urinary bladder.
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- Phthalocyanines
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Storage-stable aqueous compositions containing dissolved water-soluble novel acid addition salts of poly(N-substituted sulfonamido) phthalocyanines which are prepared by the interaction of a single acid or a mixture of acids and poly(N-substituted sulfonamido) phthalocyanines, are useful for direct dyeing, particularly the dyeing of cellulose.
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- Novel monoazo and disazo colorants
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This invention relates to novel (N-substituted sulfonamido) monoazo and disazo compounds, to acid-addition salts of said azo compounds which are useful as direct dyes particularly in the dyeing of cellulose, to novel (N-substituted sulfonamido) substituted nitrobenzene, aniline and acetanilide intermediates to said azo compounds and to methods of preparation of said azo compounds and said intermediates to said azo compounds.
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- N-Aminoalkylenesulfonamido substituted monoazo colorants
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This invention relates to novel mixtures consisting essentially of monoazo compounds and disazo compounds which are substituted with x (N-substituted sulfonamido) groups, to acid-addition salts of said azo compounds, useful as direct dyes particularly in the dyeing of cellulose, and to methods of preparation of said mixtures of (N-substituted sulfonamido) substituted monoazo and disazo compounds.
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- Novel compositions and processes
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Storage-stable aqueous compositions containing dissolved water-soluble novel acid addition salts of poly(N-substituted sulfonamido) phthalocyanines which are prepared by the interaction of a single acid or a mixture of acids and poly(N-substituted sulfonamido) phthalocyanines, are useful for direct dyeing, particularly the dyeing of cellulose.
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- Long-range anisotropic effects of long chain amides
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In 1H-NMR spectra of amids with long-chain aliphatic N-substituents one observes - despite of the free mobility of the aliphatic chain - splitting of the signals of the terminal methyl groups which is caused by the hindered rotation of the amide bond. - Keywords: Amides; Hindered rotation; 1H-NMR
- Budzikiewicz, Herbert,Vieth, Peter-Eric,Krueger, Uwe
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p. 825 - 840
(2007/10/02)
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- 2'-(4,6-Disubstituted)-s-triazin-2-yl)amino-6'-dialkylamino flurans
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Fluorans useful as color precursors, particularly in the art of carbonless duplicating are normally colorless and are represented by the structural formula STR1 wherein R represents non-tertiary alkyl of one to four carbon atoms; R1 and R2 represent hydrogen or non-tertiary alkyl of one to four carbon atoms; R3 and R4 represent chlorine, NH2 or one of the groups --NR5 -(lower-alkylene)-N(R6)(R7), --NR5 -(lower-alkylene-N(R8)(R9)(R10) An, -NR5 -(lower-alkylene)-OH, -NR5 -(lower-alkylene) STR2 --NR5 -(HSO3 -C6 H4) or --O-(lower-alkylene)-N(R8)(R9) in which R5, R6 and R7 represent hydrogen or non-tertiary alkyl of one to four carbon atoms; R8 and R9 represent non-tertiary alkyl of one to four carbon atoms; R10 represents non-tertiary alkyl of one to four carbon atoms, benzyl or benzyl substituted in the benzene ring by one or two of halo or alkyl of one to three carbon atoms; and An represents an anion.
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- Triazinyl-benzofluorans
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Fluorans useful as color precursors, particularly in the art of carbonless duplicating are normally colorless and are represented by the structural formula STR1 wherein R represents non-tertiary alkyl of one to four carbon atoms; R1 and R2 represent hydrogen or non-tertiary alkyl of one to four carbon atoms; R3 and R4 represent chlorine, or one of the groups --NR5 -(lower-alkylene)-N(R6)(R7) or --NR5 -(lower-alkylene-N+ (R8)(R9)(R10) An- , in which R5, R6 and R7 represent hydrogen or non-tertiary alkyl of one to four carbon atoms; R8 and R9 represent non-tertiary alkyl of one to four carbon atoms, R10 represents non-tertiary alkyl of one to four carbon atoms, benzyl or benzyl substituted in the benzene ring by one or two of halo or alkyl of one to three carbon atoms; and An represents an anion.
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- Triazinyl-benzofluorans
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Fluorans useful as color precursors, particularly in the art of carbonless duplicating are normally colorless and are represented by the structural formula STR1 wherein R represents non-tertiary alkyl of one to four carbon atoms; R1 represents hydrogen or non-tertiary alkyl of one to four carbon atoms; R2 and R3 represent chlorine or one of the groups --NR4 --(lower-alkylene)--N(R5)(R6) or --NR4 --(lower-alkylene)--N+(R7)(R8)(R9)An- In which R4, R5 and R6 represent hydrogen or non-tertiary alkyl of one to four carbon atoms; R7 and R8 represent non-tertiary alkyl of one to four carbon atoms; R9 represents non-tertiary alkyl of one to four carbon atoms, benzyl or benzyl substituted in the benzene ring by one or two of halo or alkyl of one to three carbon atoms; and An represents an anion.
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