cas 122918-25-6, 6-Bromo-2-pyridinecarbonitrile

Articles about 122918-25-6Total 6 be found

Synthesis and antiprotozoal activity of pyridyl analogues of pentamidine
A series of novel pyridyl analogues 1-18 of antiprotozoal drug 1,5-bis(4-amidinophenoxy)pentane (pentamidine) has been synthesized and tested for in vitro activities against Trypanosoma brucei rhodesiense, Plasmodium falciparum, and Leishmania donovani, a
Bakunova, Svetlana M.,Bakunov, Stanislav A.,Wenzler, Tanja,Barszcz, Todd,Werbovetz, Karl A.,Brun, Reto,Tidwell, Richard R.
p. 4657 - 4667
(2009)
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2-Cyano-pyrimidines: A new chemotype for inhibitors of the cysteine protease cathepsin K
Starting from the purine lead structure 1, a new series of cathepsin K inhibitors based on a pyrimidine scaffold have been explored. Investigations of P3 and P2 substituents based on molecular modeling suggestions resulted in potent cathepsin K inhibitors
Altmann, Eva,Aichholz, Reiner,Betschart, Claudia,Buhl, Thomas,Green, Jonathan,Irie, Osamu,Teno, Naoki,Lattmann, René,Tintelnot-Blomley, Marina,Missbach, Martin
p. 591 - 594
(2007)
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Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity
A series of phidianidine B derivatives were synthesized by introducing various heterocyclic rings. Their inhibitory effects on PTP1B and other PTPs (TCPTP, SHP1, SHP2 and LAR) were evaluated. A majority of them displayed significant inhibitory potency and specific selectivity over PTP1B. The SAR and molecular docking analysis were also described.
Zhang, Li,Jiang, Cheng-Shi,Gao, Li-Xin,Gong, Jing-Xu,Wang, Zhong-Hua,Li, Jing-Ya,Li, Jia,Li, Xu-Wen,Guo, Yue-Wei
p. 778 - 781
(2016)
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A convenient reagent for the conversion of aldoximes into nitriles and isonitriles
For the dehydroxylation of aldoximes with 4-nitro-1-((trifluoromethyl)sulfonyl)-imidazole (NTSI), slight modifications of reaction conditions resulted in significantly different reaction paths to provide either nitriles or isonitriles. The challenging conversion of aldoximes into isonitriles was achieved under mild conditions.
Zhang, Wei,Lin, Jin-Hong,Zhang, Pengfei,Xiao, Ji-Chang
supporting information
p. 6221 - 6224
(2020/06/29)

Efficient enhancement of copper-pyridineoxazoline catalysts through immobilization and process design
Copper-pyridineoxazoline (Cu-pyox) complexes are poor homogeneous catalysts for asymmetric cyclopropanation reactions. Pyox ligands have been immobilized by polymerization of monomers possessing a vinyl group directly attached to position 6 with styrene a
Aranda,Cornejo,Fraile,Garcia-Verdugo,Gil,Luis,Mayoral,Martinez-Merino,Ochoa
supporting information; experimental part
p. 983 - 990
(2011/06/19)

Method of converting functional group through halogen-metal exchange reaction
A method by which a halogen atom of a halogen compound can be efficiently replaced with an electrophilic group. Also provided are: a reagent for converting a functional group through a halogen-metal exchange reaction, characterized by comprising either a mixture of a magnesium compound represented by the formula R1—Mg—X (I) (wherein R1 represents a halogen atom or an optionally substituted hydrocarbon residue; and X1 represents a halogen atom) and an organolithium compound represented by the formula R2—Li (II) (wherein R2 represents an optionally substituted hydrocarbon residue) or a product of the reaction of the magnesium compound with the organolithium compound; and a process for producing with the reagent a compound in which a halogen atom of a halogen compound has been replaced with an electrophilic group.
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(2008/06/13)