Synthesis, DNA/RNA affinity and antitumour activity of new aromatic diamidines linked by 3,4-ethylenedioxythiophene
A series of novel 2,5-bis(amidinophenyl)-3,4-ethylenedioxythiophenes (5-10 and 15) has been synthesized. Compounds 5-10 bind to the DNA minor groove as the dominant binding site and strongly stabilize the double helix of ct-DNA. Surprisingly, the same com
Stolic, Ivana,Miskovic, Katarina,Piantanida, Ivo,Loncar, Mirela Baus,Glavas-Obrovac, Ljubica,Bajic, Miroslav
p. 743 - 755
(2011/03/20)
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