1269935-37-6Relevant articles and documents
Synthesis, DNA/RNA affinity and antitumour activity of new aromatic diamidines linked by 3,4-ethylenedioxythiophene
Stolic, Ivana,Miskovic, Katarina,Piantanida, Ivo,Loncar, Mirela Baus,Glavas-Obrovac, Ljubica,Bajic, Miroslav
, p. 743 - 755 (2011/03/20)
A series of novel 2,5-bis(amidinophenyl)-3,4-ethylenedioxythiophenes (5-10 and 15) has been synthesized. Compounds 5-10 bind to the DNA minor groove as the dominant binding site and strongly stabilize the double helix of ct-DNA. Surprisingly, the same com