Discovery, synthesis, and structure-activity relationship development of a series of N -4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4
There is an increasing amount of literature data showing the positive effects on preclinical antiparkinsonian rodent models with selective positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu4). However, most of the data ge
Jones, Carrie K.,Engers, Darren W.,Thompson, Analisa D.,Field, Julie R.,Blobaum, Anna L.,Lindsley, Stacey R.,Zhou, Ya,Gogliotti, Rocco D.,Jadhav, Satyawan,Zamorano, Rocio,Bogenpohl, Jim,Smith, Yoland,Morrison, Ryan,Daniels, J. Scott,Weaver, C. David,Conn, P. Jeffrey,Lindsley, Craig W.,Niswender, Colleen M.,Hopkins, Corey R.
p. 7639 - 7647
(2012/01/05)
SUBSTITUTED DIOXOPIPERIDINES AND DIOXOPYRROLIDINES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION
In one aspect, the invention relates to compounds having a general structure: wherein the variables are defined herein, which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); s
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Page/Page column 35-36
(2011/06/19)
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