Highly demanding cross-metathesis in the synthesis of the C16-C30 fragment of dolabelide C
A highly demanding cross-metathesis (CM) reaction for the formation of the C24-C25 trisubstituted olefin of dolabelide C has been optimized. A difference in reactivity between the E and Z enone isomers in this reaction was uncovered, and the selection of the Z isomer of the starting enone was critical for the success of the cross-metathesis. Application to the synthesis of the C16-C30 fragment of dolabelide C is reported.
Get Best Price for1309595-83-2(4R,9S,10S,12R,E)-15-(benzyloxy)-10,12-bis((tert-butyldimethylsilyl)oxy)-4-((triethylsilyl)oxy)-6,9-dimethylpentadec-6-en-8-one