- KF/Al2O3 catalyzed one-pot three-component process for the synthesis of some 2-thioxoquinazolin-4(1h)-one derivatives
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Three component one-pot reaction for synthesis of 2-thioxoquinazolin-4(1H)- ones are given by the condensation of isatoic anhydride, primary amine and phenyl isothiocyanate by using KF/Al2O3 as a environmentally friendly catalyst.
- Hatamjafari, Farhad,Alijanichakoli, Farzad,Mohammadmohtasham, Mohammadjavad
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- Application of Deep Eutectic Solvents in the Synthesis of Substituted 2-Mercaptoquinazolin-4(3H)-Ones: A Comparison of Setected Green Chemistry Methods
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In this study, deep eutectic solvents (DESs) were used as green and eco-friendly media for the synthesis of substituted 2-mercaptoquinazolin-4(3H)-ones from different anthranilic acids and aliphatic or aromatic isothiocyanates. A model reaction on anthranilic acid and phenyl isothiocyanate was porformed in 20 choline chloride-based DESs at 80 °C to find the best solvent. Based on the product yield, choline chloride-urea (1:2) DES was found to be the most effective, while DESs acted both as solvents and catalysts. Desired compounds were prepared with moderate to good yields using stirring, microwave-assisted, and ultrasound-assisted synthesis. Significantly, higher yields were obtained with mixing and ultrasonication (16-76%), while microwave-induced synthesis showed lower effectiveness (13-49%). The specific contribution of this research is the use of DESs in combination with the above-mentioned green techniques for the synthesis of a wide range of derivatives. The structures of the synthesized compounds were confirmed by1H and13C NMR spectroscopy.
- Jerkovi?, Igor,Komar, Mario,Kraljevi?, Tatjana Gazivoda,Molnar, Maja
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- One-pot synthesis of quinazoline-2,4(1H,3H)-diones and 2- thioxoquinazolinones with the aid of low-valent titanium reagent
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(Chemical Equation Presented) An efficient, convenient, one-pot synthesis of 2,4(1H,3H)-quinazolinediones and 2-thioxoquinazolinones was accomplished in good yields via the novel reductive cyclization of ethyl 2-nitrobenzoates with isocyanates or isothioc
- Dou, Guo-Lan,Wang, Man-Man,Huang, Zhi-Bin,Shi, Da-Qing
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experimental part
p. 645 - 649
(2009/11/30)
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- 2-thio-organotin-4(3H)-quinazolinone
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Compounds of the formula: STR1 wherein X is independently halogen, lower alkyl of 1 to 6 carbon atoms, lower alkoxy of 1 to 6 carbon atoms, nitro, lower alkylsulfinyl of 1 to 6 carbon atoms, lower alkylthio of 1 to 6 carbon atoms, amino or trifluoromethyl; n is 0, 1, 2 or 3; R is hydrogen, alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, lower alkenyl of 2 to 6 carbon atoms, or lower alkynyl of 2 to 6 carbon atoms, all optionally substituted with 1 to 3 of the same or different halogen atoms; or aryl of 6 to 12 carbon atoms; or substituted aryl substituted with 1 to 3 substituents independently selected from lower alkyl of 1 to 4 carbon atoms, lower alkoxy of 1 to 4 carbon atoms, and the group --S(O)k R2 where k is 0, 1 or 2 and R2 is lower alkyl of 1 to 4 carbon atoms, nitro, cyano or halogen; and R1 is lower alkyl of 1 to 6 carbon atoms, lower cycloalkyl of 3 to 8 carbon atoms or aryl of 6 to 12 carbon atoms, provided that R and R1 are not both cyclohexyl, are fungicidal and in some cases insecticidal.
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