- 2-thioquinazolinone compound and preparation method and application thereof
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The invention provides a 2-thioquinazolinone compound and a preparation method and application thereof, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: mixing an anthranilamide compound, an isothiocyanate compound, a bromide and a polar organic solvent, and carrying out a series cyclization reaction in an air atmosphere to obtain the 2-thioquinazolinone compound. According to the preparation method, the 2-thioquinazolinone compound can be prepared by one-step reaction without adding a catalyst, the yield and the purity of the product are high, the reaction route is simple, the operation is simple, and the preparation method is suitable for industrial production.
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Paragraph 0053; 0086-0091
(2021/09/08)
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