cas 13171-25-0, Trimetazidine dihydrochloride | Articles data ｜lookchem

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13171-25-0

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Synthesis method of trimetazidine hydrochloride
The invention provides a synthesis method of trimetazidine hydrochloride, which comprises the following steps: carrying out hydroamination reaction by using 2,3,4-trimethoxybenzaldehyde and piperazineanhydrous as raw materials, and catalyzing by using a Lindlar catalyst. The trimetazidine hydrochloride produced by the method does not contains trimetazidine hydrochloride impurity B and has high purity.
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Paragraph 0038-0055

(2020/02/14)

Method for preparing trimetazidine dihydrochloride
The invention discloses a method for preparing trimetazidine dihydrochloride. The method includes steps of (1), dissolving piperazine into solvents and adding acid into the solvents to obtain piperazine salt; (2), adding 2, 3, 4-trimethoxy benzaldehyde, cetyl trimethyl ammonium bromide and nickel catalysts into the product obtained at the step (1) and carrying out catalytic hydrogenation reaction; (3), separating reaction products to obtain oily substances after the reaction is completely carried out, acidifying the oily substances by the aid of hydrochloric acid and crystallizing the oily substances to obtain the trimetazidine dihydrochloride. The method has the advantage of mild and safe reaction conditions and simplicity and convenience in operation. Besides, the usage of the piperazine can be reduced, the trimetazidine dihydrochloride prepared by the aid of the method is high in purity and yield, and the production cost can be reduced.
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Paragraph 0027; 0028; 0029; 0030; 0031

(2017/07/11)

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Chemical Properties

Appearance/Colour :crystalline solid
Melting Point: 231-235 °C
Boiling Point: 364 °C at 760 mmHg
Flash Point:174 °C
Solubility:Freely soluble in water, sparingly soluble in alcohol.
Storage Temp.:Refrigerator
Vapor Pressure: 1.73E-05mmHg at 25°C
Merck: 14,9705
PSA: 42.96000
LogP: 2.98830

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