Pyrazoline Biphosphonate Esters as Novel Antiinflammatory and Antiarthritic Agents
Vinylidenebisphosphonic acid tetraethyl ester (1) and diazo ketones 7a-l in ether at 22 deg C yield pyrazoline biphosphonate tetraethyl esters 8a-l in moderate to good yield.These compounds were evaluated in animal models of arthritis: rat adjuvant-induce
Nugent, Richard A.,Murphy, Megan,Schlachter, Stephen T.,Dunn, Colin J.,Smith, Robert J.,et al.
p. 134 - 139
(2007/10/02)
Geminal bisphosphonic acids and derivatives as anti-arthritic agents
Unsaturated geminal phosphonates (III) STR1 either as the esters, free acids or salts are useful in the treatment of arthritis.
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(2008/06/13)
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