132508-02-2Relevant articles and documents
Pyrazoline Biphosphonate Esters as Novel Antiinflammatory and Antiarthritic Agents
Nugent, Richard A.,Murphy, Megan,Schlachter, Stephen T.,Dunn, Colin J.,Smith, Robert J.,et al.
, p. 134 - 139 (2007/10/02)
Vinylidenebisphosphonic acid tetraethyl ester (1) and diazo ketones 7a-l in ether at 22 deg C yield pyrazoline biphosphonate tetraethyl esters 8a-l in moderate to good yield.These compounds were evaluated in animal models of arthritis: rat adjuvant-induce