- Benzo[e]indolium derivatives in aqueous solutions: Reaction with bisulfite and successive interaction with Cu2+ and Hg2+
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A new benzo[e]indolium derivative 1 including pyridyl and thienyl groups was synthesized and characterized, which failed to response to Hg2+ or Cu2+ in aqueous system. However, it is interesting that when it reacted with bisulfite in
- Zeng, Rongqing,Li, Qing,Li, Zhe,Li, Xianghong,Xie, Chaoyi,Su, Xianlong,Tang, Dingguo
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- A highly sensitive and selective colorimetric probe based on a cycloruthenated complex: An Hg2+-promoted switch of thiophene coordination
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A cyclometalated ruthenium complex [Ru(pthb)(bpy)2]+ (1, bpy = 2,2′-bipyridine, Hpthb = 3,3-dimethyl-2-(5-pyridylthiophen-2-yl)vinyl-benzo[e]indolium-1-propylsulfonate) could be converted from a C-coordinated structure to non-metallated species with N,S-bonded Hpthb upon treatment with mercury(ii) ions in water. Strikingly, the switch in the coordination mode resulted in a great absorption change along with a change in the solution color of 1 from dark red to light yellow. Therefore, 1 can be used as a colorimetric probe to detect mercury(ii) ions by the naked eye. Although the emission was not observed for 1 in water, it still demonstrated an appreciably low detection limit of 21 nM by using UV-Vis absorption spectroscopy, which was comparable with those of some probes determined by ratiometric fluorescence spectroscopy.
- Du, Kang,Li, Xianghong,Tang, Dingguo,Wu, Yuhao,Xie, Chaoyi,Zhang, Bingguang
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p. 2024 - 2032
(2020/02/20)
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- Colorimetric probe capable of continuously detecting hydrogen sulfate and mercury ions and synthesis method and application thereof
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The invention discloses a colorimetric probe capable of continuously detecting hydrogen sulfate and mercury ions and a synthesis method and application thereof. The colorimetric probe is prepared by successive reactions of 2-halogenated pyridine, 5-aldehyde-2-thiopheneboronic acid, [Ru(cycme)Cl2]2, 2,2'-bipyridyl and 3-ethyl-2,3-dihydro-1,1,2-trimethyl-1H-benzo[e]indolehexafluorophosphate. The colorimetric probe can respectively or continuously detect HSO3 and Hg in a water solution, and especially has a more obvious in-situ detection effect on Hg after an action with HSO3. The colorimetric probe of the invention has high sensitivity and good selectivity.
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Paragraph 0044-0047
(2019/10/08)
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- Catalytic Deprotonative α-Formylation of Heteroarenes by an Amide Base Generated in Situ from Tetramethylammonium Fluoride and Tris(trimethylsilyl)amine
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Heteroarene formylations in DMF solution proceed in the presence of an amide base catalyst generated in situ from tetramethylammonium fluoride (TMAF) and tris(trimethylsilyl)amine (N(TMS)3). The reaction proceeds at room temperature and has an operationally simple procedure. Various heteroarenes, including benzothiophene, thiophene, benzothiazole, oxazole, and indole derivatives, can be formylated with high functional group tolerance.
- Shigeno, Masanori,Fujii, Yuki,Kajima, Akihisa,Nozawa-Kumada, Kanako,Kondo, Yoshinori
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p. 443 - 451
(2019/04/30)
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- Regioselective oxidative Pd-catalysed coupling of alkylboronic acids with pyridin-2-yl-substituted heterocycles
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A total of 19 alkylated heterocycles (thiophenes, benzothiophenes, pyrroles, furans) were prepared (36-99% yield) from the respective pyridin-2-yl-substituted precursors employing alkylboronic acids as the C-H alkylating reagents in an oxidative (Ag2
- Wippich, Julian,Schnapperelle, Ingo,Bach, Thorsten
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supporting information
p. 3166 - 3168
(2015/06/11)
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- PIPERIDINE-CONTAINING COMPOUNDS AND USE THEREOF
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A method for preventing and/or treating a metabolic disease, cerebrovascular disease, etc. which comprises administering to a mammal an effective amount of the compound of the formula (I) wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. And a novel compound of the formula (I-1): wherein all symbols have the same meanings as defined in the specification; a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof has an anti-diabetic effect and a neuroprotective effect. Accordingly, the compound of the formula (I) and the compound of the formula (I-1) are useful in a method for preventing and/or treating for a metabolic disease such as diabetes, cerebrovascular disease such as stroke, etc.
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Page/Page column 112
(2010/08/04)
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- Nonlinear optical chromophores with isoquinolines, thieno[2,3-c]-pyridines and 2-(2′-thienyl)pyridines as inherently polarized π-electron bridges
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The synthesis and first hyperpolarizabilities of a series of isoquinolines and isoquinolinium salts, and also thienopyridines, thienylpyridines, and the corresponding pyridinium salts, determined by hyper-Rayleigh scattering in solution at 1064 and 1300 nm, are reported. These chromophores exhibit markedly high β values. Some of them show absorption maxima well below 400 nm, enabling their use in blue transparent frequency doubling devices. We have performed X-ray structure analyses for thienopyridines 13a,c.
- Nerenz, Heiko,Meier, Martin,Grahn, Walter,Reisner, Axel,Schmaelzlin, Elmar,Stadler, Stefan,Meerholz, Klaus,Braeuchle, Christoph,Jones, Peter G.
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p. 437 - 447
(2007/10/03)
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- Coupling of Organotin Reagents with Aryl, Acyl and Heteroaryl Halides Part Two: Synthesis of Thienylpyridine Derivatives
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Coupling of organotin reagent Bu3SnAr (Ar = 2- or 3-pyridyl, or 2- or 3-thienyl) with appropriately halogenated heterocyclic in the presence of PdCl(CH2Ph)(PPh3)2 leads to the corresponding thienylpyridine derivative.Functionality is tolerated on the thiophene centre, but not in the case of the corresponding pyridine analogue.The compounds Bu3SnAr were prepared by a variety of methods, giving good yield of the tri-n-butylstannylated heterocycle.Other derivatives are prepared by direct reaction with the thienylpyridine nucleus.Examples of homo-coupling of the both organotin compounds and the aryl halide are also reported.
- Sosabowski, Michael H.,Powell, Paul
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p. 201 - 219
(2007/10/03)
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- UREA BASED LIPOXYGENASE INHIBITING COMPOUNDS
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Substituted phenyl, naphthyl, and thienyl N-hydroxy urea compounds form a class of potent inhibitors of 5-and 12-lipoxygenase and are thus useful compounds in the treatment of inflammatory disease states where leukotrienes and other products of lipoxygenase enzyme activity are implicated.
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