132706-12-8

Basic information

• Product Name: 5-PYRIDIN-2-YLTHIOPHENE-2-CARBALDEHYDE
• Synonyms: 5-(2-PYRIDINYL)-2-THIOPHENECARBALDEHYDE;5-PYRIDIN-2-YLTHIOPHENE-2-CARBALDEHYDE;5-PYRIDIN-2-YLTHIOPHENE-2-CARBOXALDEHYDE;AKOS BAR-1671;5-(2-Pyridinyl)thiophene-2-carbaldehyde;5-pyridin-2-ylthiophen-2-carbaldehyde;2-Thiophenecarboxaldehyde, 5-(2-pyridinyl)-
• CAS NO: 132706-12-8
• Molecular Formula: C₁₀H₇NOS
• Molecular Weight: 189.23
• Product Categories: Aldehydes;Thiophenes & Benzothiophenes;Thiophenes & Benzothiophenes
• Mol File: 132706-12-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 122-125°C
• Boiling Point: 356.1 °C at 760 mmHg
• Flash Point: 169.2 °C
• Appearance: /
• Density: 1.269 g/cm³
• Vapor Pressure: 2.99E-05mmHg at 25°C
• Refractive Index: 1.645
• PKA: 3.13±0.19(Predicted)
• CAS DataBase Reference: 5-PYRIDIN-2-YLTHIOPHENE-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PYRIDIN-2-YLTHIOPHENE-2-CARBALDEHYDE(132706-12-8)
• EPA Substance Registry System: 5-PYRIDIN-2-YLTHIOPHENE-2-CARBALDEHYDE(132706-12-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 132706-12-8(Hazardous Substances Data)

Usage

General Description

5-Pyridin-2-ylthiophene-2-carbaldehyde is a chemical compound with the molecular formula C12H9NOS. It is a yellow to orange solid that is used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. The compound contains a pyridine ring and a thiophene ring, both of which are heterocyclic aromatic structures that contribute to its reactivity and chemical properties. 5-Pyridin-2-ylthiophene-2-carbaldehyde is commonly used in organic synthesis as a building block for creating more complex molecules, and it has potential applications in the fields of medicinal chemistry and materials science. Its chemical structure and properties make it a versatile and valuable component in the development of new chemical compounds and materials.

InChI:InChI=1/C10H7NOS/c12-7-8-4-5-10(13-8)9-3-1-2-6-11-9/h1-7H

Upstream product

• 3319-99-1 2'-(2-thienyl)pyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 4701-17-1 5-bromo-2-thiophencarboxaldehyde 
• 2591-86-8 N-Formylpiperidine 
• 109-04-6 2-bromo-pyridine 
• 197899-76-6 5-(pyrid-2-yl)-2-hydroxymethyl thiophene 
• 52157-62-7 2-(5-bromothiophen-2-yl)-1,3-dioxolane 
• 123784-07-6 2-(5-bromothiophen-2-yl)pyridine 

Downstream Products

• 1429192-67-5 1-methyl-3-phenyl-2-(5-(pyridin-2-yl)thiophen-2-yl)-2,3-dihydroquinazolin-4(1H)-one 
• 1429192-12-0 3-phenyl-2-(5-(pyridin-2-yl)thiophen-2-yl)-2,3-dihydroquinazolin-4(1H)-one 

Relevant articles and documents

Benzo[e]indolium derivatives in aqueous solutions: Reaction with bisulfite and successive interaction with Cu2+ and Hg2+

A new benzo[e]indolium derivative 1 including pyridyl and thienyl groups was synthesized and characterized, which failed to response to Hg2+ or Cu2+ in aqueous system. However, it is interesting that when it reacted with bisulfite in

Catalytic Deprotonative α-Formylation of Heteroarenes by an Amide Base Generated in Situ from Tetramethylammonium Fluoride and Tris(trimethylsilyl)amine

Heteroarene formylations in DMF solution proceed in the presence of an amide base catalyst generated in situ from tetramethylammonium fluoride (TMAF) and tris(trimethylsilyl)amine (N(TMS)3). The reaction proceeds at room temperature and has an operationally simple procedure. Various heteroarenes, including benzothiophene, thiophene, benzothiazole, oxazole, and indole derivatives, can be formylated with high functional group tolerance.

Regioselective oxidative Pd-catalysed coupling of alkylboronic acids with pyridin-2-yl-substituted heterocycles

A total of 19 alkylated heterocycles (thiophenes, benzothiophenes, pyrroles, furans) were prepared (36-99% yield) from the respective pyridin-2-yl-substituted precursors employing alkylboronic acids as the C-H alkylating reagents in an oxidative (Ag2