- METALLO-BETA-LACTAMASE INHIBITORS AND METHODS OF USE THEREOF
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The present invention relates to metallo-β-lactamase inhibitor compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X2 and R1 are as defined herein. The present invention also relates to compositions which comprise a metallo-β-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.
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Page/Page column 70
(2019/02/06)
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- METALLO-BETA-LACTAMASE INHIBITORS
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The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.
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Page/Page column 46; 47
(2017/04/04)
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- Largely blue-shifted emission through minor structural modifications: Molecular design, synthesis, aggregation-induced emission and deep-blue OLED application
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By simply introducing additional groups with different size and conjugation degree to the 2,2′-positions of BTPE, four BTPE derivatives are prepared which give blue or deep-blue EL emissions when used as emitters in non-doped OLEDs, as the result of the tuned dihedral angles of the biphenyl cores (up to ～89°), providing a new approach to design AIE luminogens with blue and deep-blue emissions. The Royal Society of Chemistry.
- Huang, Jing,Sun, Ning,Chen, Pengyu,Tang, Runli,Li, Qianqian,Ma, Dongge,Li, Zhen
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supporting information
p. 2136 - 2138
(2014/02/14)
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- The synthesis and mesomorphic properties of 2,2′,3-tri- and 2,2′,3,3′-tetra-fluoro-1,1′:4′,1″-terphenyls for high dielectric biaxiality ferroelectric liquid crystal mixtures
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Liquid crystalline 1,1′:4′,1″-terphenyls with three and four lateral fluoro substituents and alkyl or alkoxy substituents in the 4- and 4′-positions have been synthesised. Synthetic strategies employed were convergent and involved the use of arylboronic acids and aryl halides in palladium-catalysed cross-coupling reactions. These syntheses are of particular interest because issues of selective metallation (at positions ortho to a fluoro substituent) and selective coupling reactions (bromo versus iodo sites) are involved, not all of which proceed as expected. All the trifluoroterphenyls and most of the tetrafluoroterphenyls generate the smectic C phase, the phase stability and temperature range of which were found to be highly dependent upon the relative lengths of the two terminal chains. The 2,2′,3- and 2,2′,3,3′-patterns of lateral fluoro substitution in 1,1′:4′,1″-terphenyls generate materials of high lateral dipole and enable the formulation of ferroelectric mixtures with a high dielectric biaxiality which is very important in τV minimum driving schemes.
- Glendenning, Margaret E.,Goodby, John W.,Hird, Michael,Toyne, Kenneth J.
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p. 481 - 491
(2007/10/03)
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- Anisotropic organic compounds
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STR1 The invention describes liquid crystalline compounds or formula (I), where A, D and G are independently selected from phenyl, thiophene, hydrogenated phenyl, chlorinated phenyl and fluorinated phenyl, B and E are independently selected from a single bond C= C. C C.C00, azoxy and diazo, k and m are independently selected from 1 and 0, such that m+n is 1 or 2, and R1 and R2 are independently selected from R, R0, alkynyl, thioalkyl, hydrogen, CN, NCS and SCN; provided that at least one of R1 and R2 is selected from CN, NCS and SCN and that at least one of A, D and G is phenyl; and excluding where at least one of R1 and R2 is independently selected as CN and one of A, D or G is not thiophene, and where m is 0, A, and D are phenyl, B is a single bond and only one of R1 or R2 is NCS. Also described are compounds suitable for inclusion in a device utilizing pretransitional characteristics of liquid crystalline materials in the isotropic phase, of general formula (II) where J and Y are independently selected from phenyl, thiophene, hydrogenated phenyl, chlorinated phenyl and fluorinated phenyl, X is selected from C= C. C C.COO azoxy and diazo, k is 1 or 0 and R3 and R4 are independently selected from R, RO, alkynyl, thioalkyl, hydrogen, CN, NCS and SCN; provided that at least one of R3 and R4 is selected from CN, NCS and SCN and that at least one of J and Y is phenyl.
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- Tolan derivative, liquid crystal composition containing the derivative, and liquid crystal display device having the composition
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A tolan derivative of a formula: STR1 where R represents a linear alkyl group having from 1 to 10 carbon atoms; X1, X2 and X3 independently represent a fluorine atom or a hydrogen atom, provided that one of them is necessarily a fluorine atom and the others are hydrogen atoms; and Y represents a nitrile group or a linear alkyl group having from 1 to 10 carbon atoms; and a liquid crystal composition containing the derivatives; and a liquid crystal display device having the composition are produced. The compound is compatible with other liquid crystal compounds, and by blending the compound with ordinary liquid crystal compounds, a liquid crystal composition having a broadened practical temperature range and an enlarged double refraction anisotropy is obtained.
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- Tolane derivatives, liquid crystal compositions containing the derivatives and liquid crystal display devices using the compositions
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A tolane derivative, a liquid crystal composition containing the derivative, and a liquid crystal display device including the composition, in which the tolane derivative is represented by the following general formula: STR1 wherein R represents a straigh
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- The Synthesis of Several Lateral Difluoro-substituted 4,4''-Dialkyl- and 4,4''-Alkoxyalkyl-Terphenyls and a Rationalisation of the Effect of Such Substitution on Mesophase Type and Transition Temperatures
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In recent years we have prepared a large number of mono-fluoro- and ortho-difluoro-substituted 4,4''-dialkyl- and 4,4''-alkoxyalkyl-terphenyls.The synthesis and transition temperatures of a variety of related difluoro compounds is presented here so that it is now possible to identify (i) broadening of the molecule, (ii) twisting about an inter-annular bond, and (iii) the presence of an "inner" (2-, 2'-, 3'- or 2''-substituent) or an "outer" (3- or 3''-substituent) fluorine, as being the major factors which influence the type and the thermal stability of the mesophases obtained.
- Gray, G. W.,Hird, M.,Toyne, K. J.
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