136434-77-0Relevant articles and documents
METALLO-BETA-LACTAMASE INHIBITORS AND METHODS OF USE THEREOF
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, (2019/02/06)
The present invention relates to metallo-β-lactamase inhibitor compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X2 and R1 are as defined herein. The present invention also relates to compositions which comprise a metallo-β-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.
Largely blue-shifted emission through minor structural modifications: Molecular design, synthesis, aggregation-induced emission and deep-blue OLED application
Huang, Jing,Sun, Ning,Chen, Pengyu,Tang, Runli,Li, Qianqian,Ma, Dongge,Li, Zhen
, p. 2136 - 2138 (2014/02/14)
By simply introducing additional groups with different size and conjugation degree to the 2,2′-positions of BTPE, four BTPE derivatives are prepared which give blue or deep-blue EL emissions when used as emitters in non-doped OLEDs, as the result of the tuned dihedral angles of the biphenyl cores (up to ～89°), providing a new approach to design AIE luminogens with blue and deep-blue emissions. The Royal Society of Chemistry.
The synthesis and mesomorphic properties of 2,2′,3-tri- and 2,2′,3,3′-tetra-fluoro-1,1′:4′,1″-terphenyls for high dielectric biaxiality ferroelectric liquid crystal mixtures
Glendenning, Margaret E.,Goodby, John W.,Hird, Michael,Toyne, Kenneth J.
, p. 481 - 491 (2007/10/03)
Liquid crystalline 1,1′:4′,1″-terphenyls with three and four lateral fluoro substituents and alkyl or alkoxy substituents in the 4- and 4′-positions have been synthesised. Synthetic strategies employed were convergent and involved the use of arylboronic acids and aryl halides in palladium-catalysed cross-coupling reactions. These syntheses are of particular interest because issues of selective metallation (at positions ortho to a fluoro substituent) and selective coupling reactions (bromo versus iodo sites) are involved, not all of which proceed as expected. All the trifluoroterphenyls and most of the tetrafluoroterphenyls generate the smectic C phase, the phase stability and temperature range of which were found to be highly dependent upon the relative lengths of the two terminal chains. The 2,2′,3- and 2,2′,3,3′-patterns of lateral fluoro substitution in 1,1′:4′,1″-terphenyls generate materials of high lateral dipole and enable the formulation of ferroelectric mixtures with a high dielectric biaxiality which is very important in τV minimum driving schemes.
