Synthesis and Muscarinic Cholinergic Receptor Affinities of 3-Quinuclidinyl α-(Alkoxyalkyl)-α-aryl-α-hydroxyacetates
Seven analogues of 3-quinuclidinyl benzilate (QNB) in which one phenyl ring was replaced by an alkoxyalkyl moiety were synthesized and their affinities for the muscarinic cholinergic receptor determined.An oxygen in the β-position of the moienty was not w
Cohen, Victor I.,Gibson, Raymond E.,Fan, Linda H.,Cruz, Rosanna De La,Gitler, Miriam S.,et al.
Indium tribromide: A highly effective catalyst for the addition of trimethylsilyl cyanide to α-hetero-substituted ketones
The catalytic addition of trimethylsilyl cyanide (TMSCN) to a large variety of hetero-substituted ketones promoted by anhydrous InBr3 has been studied. The low catalytic loading (0.1-1 mol%) and the mild experimental conditions required represe
A convenient catalytic procedure for the addition of trimethylsilyl cyanide to functionalised ketones, mediated by InBr3 - Insight into the reaction mechanism
This paper describes a useful and practical methodology for the addition of trimethylsilyl cyanide (TMSCN) to a large variety of functionalised and unfunctionalised ketones in the presence of catalytic amounts of anhydrous InBr3. The optimum pr