- The Total Synthesis of Spermine Alkaloid Kukoamine Bimesylate
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The first total synthesis of kukoamine B bimesylate was completed from 1,4-diaminobutane dihydrochloride in 12 steps with a 11.4% overall yield, and all the steps could be carried out at a kilogram scale. The cyano groups were used as the precursor of amino groups to avoid the competitive reaction delicately. The aza-Michael addition reaction, amidation and hydrogenation of the cyano group sequence was streamlined as a general approach towards the synthesis of polyamine structures.
- Dong, Kai
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supporting information
p. 2669 - 2672
(2018/12/14)
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- Polyamine derivative medicinal salt and its preparation method and use
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The invention relates to a polyamine derivative medicinal salt and its preparation method and use in preparation of a drug for treating pyemia. The novel compound has good antagonistic action on a plurality of pyemia-causing pathogen-related molecules such as bacterial lipopolysaccharide (endotoxin), bacterial genome DNA, peptidoglycan, teichoic acid, virus RNA and zymosan, and can be used for preparation of a drug for treating pyemia.
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Paragraph 0079; 0080
(2016/10/17)
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- SALTS OF KUKOAMINE B, PREPARATION METHOD AND USE THEREOF
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Provided are salts of kukoamine B, their preparation method and their use in preventing and treating sepsis diseases.
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Paragraph 0036
(2013/09/26)
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- SALTS OF KUKOAMINE B, PREPARATION METHOD AND USE THEREOF
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Salts of kukoamine B, their preparation method and their pharmaceutical use in preparation of drugs for preventing and treating sepsis. Experiments indicate that salts of kukoamine B have a good effect on antagonizing the key factors inducing sepsis, and can be used in the preparation of drugs for preventing and treating sepsis. Under the current circumstances of the lack of effective measures for the treatment of sepsis in clinical practice, the medicinal formulations, which comprise the salts of kukoamine B, pharmaceutically acceptable carrier and/or diluent, provide a new approach for the prevention and treatment of sepsis.
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Paragraph 0067
(2013/11/06)
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