- Rh-Catalyzed Regioselective ortho-C-H Carbenoid Insertion of Diarylazines
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The Rh-catalyzed ortho-C-H carbenoid insertion reaction of diarylazines with diazo compounds has been developed. A wide range of ortho-substituted diarylazines have been obtained in moderate to high yields with high regioselectivity at room temperature. The hydrolysis of the products could release ketones or aldehydes, giving access to aromatic 1,5-keto-diesters as valuable synthons for further chemical transformations.
- Yu, Yunliang,Kuai, Changsheng,Chauvin, Remi,Tian, Nian,Ma, Shuangshuang,Cui, Xiuling
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p. 8611 - 8616
(2017/08/23)
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- Rh-catalyzed intermolecular carbenoid functionalization of aromatic C-H bonds by α-diazomalonates
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A Rh-catalyzed intermolecular coupling of diazomalonates with arene C-H bonds is reported. The reaction is initiated by electrophilic C-H activation, which is followed by coupling of the arylrhodium(III) complex with the diazomalonate. In most cases, arenes with oximes, carboxylic acids, and amines as directing groups cross-couple with diazomalonates with excellent regioselectivities and functional group tolerance, and thus, this reaction offers a new route to α-aryl carbonyl compounds for specific applications.
- Chan, Wai-Wing,Lo, Siu-Fung,Zhou, Zhongyuan,Yu, Wing-Yiu
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p. 13565 - 13568
(2012/10/08)
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