- Micro-reaction system and method for continuously preparing 2-amino-1,3-diol compounds
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The invention belongs to the technical field of pharmaceutical engineering, and particularly relates to a micro-reaction system and method for continuously preparing 2-amino-1,3-diol compounds. The micro-reaction system comprises a micro-mixer and a micro-channel reactor which communicate with each other in sequence; the micro-mixer is used for mixing a solution of a raw material 2-nitro-1,3-diol compound with hydrogen; and the micro-channel reactor is used for continuous reaction of the mixture. The method comprises the following steps: packing a palladium catalyst in the microchannel reactor, dissolving a 2-nitro-1,3-diol compound in an organic solvent, conveying the dissolved 2-nitro-1,3-diol compound and hydrogen into the microchannel reactor at the same time, and carrying out a continuous catalytic hydrogenation reaction to obtain the corresponding 2-amino-1, 3-diol compound. According to the method, the reaction time is only several minutes, the yield of the product 2-amino-1,3-diol compound is larger than 99%, the technological process is continuous, the automation degree is high, the space time yield is high, operation is easy and convenient, the step of separating reaction liquid from a catalyst is not needed, cost is low, and the method is environmentally friendly, safe and easy for industrial production.
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Paragraph 0040-0041
(2021/08/06)
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- NEW STRATEGY FOR RACEMIZATION OF 2-AMINO-1,3-PROPANEDIOLS, KEY INTERMEDIATES FOR THE SYNTHESIS OF ANTIBIOTIC DRUGS
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A new strategy for racemization of the 2-amino-1,3-propanediol 2b, based on a chemoselective oxazoline ring formation and a highly diastereoselective reduction of the ketone 4 is reported.
- Giordano, Claudio,Cavicchioli, Silvia,Levi, Silvio,Villa, Marco
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p. 5561 - 5564
(2007/10/02)
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