- N-ARYLYLMETHYLINDAZOLE MODULATORS OF PPARG
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The invention provides molecular entities that bind with high affinity to PPARG (PPARy), inhibit cdJk5-mediated phosphorylation of PP ARG, but do not exert an agonistic effect on PPARG. Compounds of the invention can be used for treatment of conditions in patients wherein PPARG plays a role, such as diabetes or obesity. Methods of preparation of the compounds, bioassay methods for evaluating compounds of the invention as non-agonistic PPARG binding compounds, and pharmaceutical compositions are also provided.
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- Heterocyclic compounds having angiotensin II antagonistic activity and use thereof
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This invention relates to a compound represented by the formula STR1 wherein the ring A stands for a 5-10 membered aromatic heterocyclic group optionally having, besides R1 and R2, further substituents; R1 stands for an op
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- Cyclic compounds and their use
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The present invention relates to a compounds represented by the following formula or salts thereof. STR1 The above compounds have strong angiotensin II antagonistic action, antihypertensive action and action on central nervous system, which are useful for
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- Process for producing 4-bromomethylbiphenyl compounds
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A process for the production of a compound of general formula STR1 wherein R represents cyano, carboxy which may be esterified or amidated or tetrazolyl which may be substituted, comprising brominating the corresponding methyl compound with a brominating agent such as N -bromoacetamide, N-bromophtalimide, N-bromosuccinimide and so on in a halogenated hydrocarbon solvent in the presence of an azobis compound.
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