Application of crystallization-induced asymmetric transformation to a general, scalable method for the resolution of 2,8-disubstituted Troeger's base derivatives
A general method for the gram scale resolution of 2-substituted and 2,8-disubstituted Troeger's base (TB) derivatives in 63-91% yield has been achieved through the application of crystallization-induced asymmetric transformation (CIAT). Enantiomeric ratios of the resolved TB derivatives range from 99.1:0.9 to >99.5:0.5. Among the Troeger's base compounds resolved are four synthetically valuable bromo and iodo derivatives.
Jameson, Donald L.,Field, Thomas,Schmidt, Monica R.,Destefano, Alyson K.,Stiteler, Christopher J.,Venditto, Vincent J.,Krovic, Brooke,Hoffman, Christopher M.,Ondisco, Matthew T.,Belowich, Matthew E.
p. 11590 - 11596
(2013/12/04)
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