1478192-90-3Relevant articles and documents
Application of crystallization-induced asymmetric transformation to a general, scalable method for the resolution of 2,8-disubstituted Troeger's base derivatives
Jameson, Donald L.,Field, Thomas,Schmidt, Monica R.,Destefano, Alyson K.,Stiteler, Christopher J.,Venditto, Vincent J.,Krovic, Brooke,Hoffman, Christopher M.,Ondisco, Matthew T.,Belowich, Matthew E.
, p. 11590 - 11596 (2013/12/04)
A general method for the gram scale resolution of 2-substituted and 2,8-disubstituted Troeger's base (TB) derivatives in 63-91% yield has been achieved through the application of crystallization-induced asymmetric transformation (CIAT). Enantiomeric ratios of the resolved TB derivatives range from 99.1:0.9 to >99.5:0.5. Among the Troeger's base compounds resolved are four synthetically valuable bromo and iodo derivatives.