- A non-natural amino acid N - tert-butoxycarbonyl - L - 2 - amino - 4 - bromo - 4 - pentenoic acid preparation method (by machine translation)
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The invention relates to a non-natural amino acid N - tert-butoxycarbonyl - L - 2 - amino - 4 - bromo - 4 - preparation of pentenoic acid method, mainly solves the original synthetic method step more, cycle is long, and high cost. The technical scheme of the present invention is: the 2, 3 - dibromo propylene and acetyl malonic acid alkali pulls out the hydrogen layer which the system results in the bromine propylene acetyl amino-malonic acid diethyl ester intermediate. [...] malonic acid diethyl ester intermediate is saponified, split, on uncle butoxycarbonyl protecting group gets the N - tert-butoxycarbonyl - L - 2 - amino - 4 - bromo - 4 - pentenoic acid. Non-natural amino acid N - tert butoxycarbonyl - L - 2 - amino - 4 - bromo - 4 - pentenoic acid and intermediate is an important raw material in the field of polypeptide synthesis. (by machine translation)
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Paragraph 0032
(2018/05/16)
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- Highly diastereoselective monoalkylation and Michael addition of N- (diphenylmethylene)glycinesultam under solid-liquid phase-transfer catalysis conditions using potassium carbonate as base
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Treatment of a sultam-derived N-(diphenylmethylene)glycinate equivalent 1 with activated (allylic and propargylic) organic bromides and with Michael acceptors under solid-liquid phase-transfer catalysis conditions, using potassium carbonate as base, affords the monoalkylated compounds with high diastereoselectivity (>97% d.e.).
- Lopez, Anna,Pleixats, Roser
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p. 1967 - 1977
(2007/10/03)
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- N-(Boc)-L-(2-bromoallyl)-glycine: A versatile intermediate for the synthesis of optically active unnatural amino acids
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N(Boc)-L-(2-bromoallyl)-glycine (1) was synthesized from diethylacetamidomalonate and 2,3-dibromopropene in a one-pot procedure (75% overall yield). The enantiomers were efficiently separated via a tandem biocatalytic kinetic hydrolytic resolution. 1 was
- Leanna,Morton
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p. 4485 - 4488
(2007/10/02)
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