149930-92-7Relevant articles and documents
A non-natural amino acid N - tert-butoxycarbonyl - L - 2 - amino - 4 - bromo - 4 - pentenoic acid preparation method (by machine translation)
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Paragraph 0032, (2018/05/16)
The invention relates to a non-natural amino acid N - tert-butoxycarbonyl - L - 2 - amino - 4 - bromo - 4 - preparation of pentenoic acid method, mainly solves the original synthetic method step more, cycle is long, and high cost. The technical scheme of the present invention is: the 2, 3 - dibromo propylene and acetyl malonic acid alkali pulls out the hydrogen layer which the system results in the bromine propylene acetyl amino-malonic acid diethyl ester intermediate. [...] malonic acid diethyl ester intermediate is saponified, split, on uncle butoxycarbonyl protecting group gets the N - tert-butoxycarbonyl - L - 2 - amino - 4 - bromo - 4 - pentenoic acid. Non-natural amino acid N - tert butoxycarbonyl - L - 2 - amino - 4 - bromo - 4 - pentenoic acid and intermediate is an important raw material in the field of polypeptide synthesis. (by machine translation)
N-(Boc)-L-(2-bromoallyl)-glycine: A versatile intermediate for the synthesis of optically active unnatural amino acids
Leanna,Morton
, p. 4485 - 4488 (2007/10/02)
N(Boc)-L-(2-bromoallyl)-glycine (1) was synthesized from diethylacetamidomalonate and 2,3-dibromopropene in a one-pot procedure (75% overall yield). The enantiomers were efficiently separated via a tandem biocatalytic kinetic hydrolytic resolution. 1 was
