Synthesis, X-ray crystallographic study, and biological evaluation of coumarin and quinolinone carboxamides as anticancer agents
A series of coumarin and quinolinone-3-aminoamide derivatives was synthesized and evaluated for its potency in inhibition of cancer cell growth. The structure of N-[2-(dimethylamino) ethyl]-4-hydroxy-2-oxo-1-phenyl-1,2- dihydroquinoline-3-carboxamide was
Matiadis, Dimitris,Stefanou, Valentina,Athanasellis, Giorgos,Hamilakis, Stylianos,McKee, Vickie,Igglessi-Markopoulou, Olga,Markopoulos, John
p. 1063 - 1069
(2013/07/26)
Design and synthesis of novel quinolinone-3-aminoamides and their α-lipoic acid adducts as antioxidant and anti-inflammatory agents
A series of N-substituted-quinolinone-3-aminoamides and their hybrids containing the α-lipoic acid functionality were designed and synthesized as potential bifunctional agents combining antioxidant and anti-inflammatory activity. The new compounds were ev
4-HYDROXY-2-QUINOLONES 7. SYNTHESIS AND BIOLOGICAL PROPERTIES OF 1-R-3-(2-BENZIMIDAZOLYL)-4-HYDROXY-2-QUINOLONES
Condensation of 1-R-3-carbethoxy-4-hydroxy-2-quinolones with o-phenylene diamine gives the corresponding 1-R-3-(2-benzimidazolyl)-4-hydroxy-2-quinolones.Data on a study of the antihyroid activity of the synthesized compounds is presented.