- Preparation method 10 - carbonyl docetaxel
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The invention discloses a preparation method of 10 - carbonyl docetaxel, and the technical scheme of the invention comprises the following steps: S1: dissolving docetaxel solvent, adding heavy metal salt, stirring and reacting, carrying out suction filtra
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Paragraph 0043-0045
(2021/11/06)
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- Facile Synthesis of 7-epi-Taxane and Its Derivatives and Preliminary Evaluation of Anticancer Activity
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7-epi-Taxane has been achieved efficiently in gram scale from natural taxane via inversion of the 7-hydroxyl group simply using Ag2O as catalyst and DMF as solvent. The catalyst could be quantitatively recovered by filtration without loss of catalytic activity. This condition is also applicable to the direct epimerization of taxane derivatives (e.g., docetaxel and paclitaxel) to 7-epi-taxane derivatives (e.g., 7-epi-docetaxel and 7-epi-paclitaxel). Furthermore, 33 ester derivatives of 7-epi-taxane with different amino acid moieties at the position of C-13 were successfully synthesized via esterification without protecting C-7-OH. Bioassay results revealed that compounds 13 and 18 have good selectivity against prostatic cancer cell line DU145, with IC50value as low as 15.9 nmol/L for 18.
- Li, Zhao,Feng, Jia,Zou, Kun,Yang, Zhuo,Zhang, Yong,Xu, Zhijian,Li, Bo,Shi, Jiye,Li, Yiming,Zhu, Weiliang,Chen, Kaixian
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p. 1165 - 1176
(2016/11/25)
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- Method for preparing 7-epi-taxane compounds
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The invention relates to a method for preparing 7-epi-taxane compounds from 7-beta-hydroxy taxane compounds. The method comprises the step of converting 7-beta-hydroxy taxane compounds into 7-epi-taxane compounds in the solvent S under the existence of a
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Paragraph 0074-0075
(2017/03/14)
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- METHOD FOR PREPARATION OF AMORPHOUS, ANHYDROUS CRYSTALLINE OR HYDRATED CRYSTALLINE DOCETAXEL
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This invention is directed to a method for the preparation of docetaxel having an amorphous, anhydrous crystalline, or hydrated crystalline structure. In accordance with the invention, highly pure amorphous, anhydrous crystalline, or hydrated crystalline docetaxel can be produced with a high yield by using a solvent precipitation method, colloid formation method, etc.
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Page/Page column 6
(2009/01/24)
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- PHARMACEUTICAL COMPOSITION CONTAINING A TAXANE DERIVATIVE, DESTINED FOR THE PREPARATION OF AN INFUSION SOLUTION, METHOD OF PREPARATION THEREOF AND USE THEREOF
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A pharmaceutical composition containing a taxane derivative, destined for the preparation of an infusion solution for administration to patients, containing a concentrate consisting of a pharmaceutically effective amount of docetaxel, a suitable solvent,
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Page/Page column 18-23
(2008/06/13)
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