- NOVEL HETEROCYCLIC DERIVATIVES AND THEIR USES
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The present invention relates to novel heterocyclic compounds useful in preparing drugs for treatment of diseases associated with various functions of the histamine 4 receptor. Especially, the said drugs are useful for treatment of inflammatory diseases, allergy, pain, nasal polyps, rhinitis, chronic sinusitis, nasal congestion, nasal itch, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis, eczema, pruritus, itchy skin, urticaria, idiopathic chronic urticaria, scleroderma, conjunctivitis, keratoconjunctivitis, ocular inflammation, dry eye, cardiac dysfunction, arrhythmia, atherosclerosis, multiple sclerosis, inflammatory bowel disease (including colitis, Crohn's disease, ulcerative colitis), inflammatory pain, neuropathic pain, osteoarthritic pain, autoimmune thyroid disease, immune-mediated (also known as type I) diabetes, lupus, post-operative adhesions, vestibular disorders and cancer.
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Paragraph 1208-1210
(2014/10/29)
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- Heterocyclizations in the pyrido[2,3-b]pyrazine series
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In this paper, we report the results of heterocyclizations in the pyrido[2,3-b]pyrazine series to give the pyrido[2,3-e] or [3,2-e]pyrrolo[1,2- a]pyrazine. The Clauson-Kaas reaction on 2,3-diaminopyridine is investigated; regioselectivity on the 3-amino group is shown by 1H- and 13C-nmr. Synthesis and reactivity of the original pyrazino[2,3-g]indolizine series is also reported.
- Blache,Gueiffier,Chavignon,Teulade,Milhavet,Viols,Chapat,Dauphin
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p. 161 - 166
(2007/10/02)
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